{"id":3801,"date":"2025-07-21T16:53:08","date_gmt":"2025-07-21T07:53:08","guid":{"rendered":"http:\/\/m12n08.jp\/blog\/?p=3801"},"modified":"2025-07-21T16:56:29","modified_gmt":"2025-07-21T07:56:29","slug":"%e6%9c%88%e9%96%9350000pv%e3%83%96%e3%83%ad%e3%82%ac%e3%83%bc%e3%81%ae%e6%9c%88%e9%96%93%e3%83%96%e3%83%ad%e3%82%b0%e5%8f%8e%e5%85%a515775%e5%86%86%ef%bc%882018%e5%b9%b410%e6%9c%88%ef%bc%89-2-2-2-2-35","status":"publish","type":"post","link":"http:\/\/m12n08.jp\/blog\/share\/4588oncolys\/3801.html","title":{"rendered":"\u30aa\u30f3\u30b3\u30ea\u30b9 Nature\u8ad6\u6587\u90a6\u8a33\uff082025.07.19\uff09\/ \u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\u306b\u3088\u308bp53\u6d3b\u6027\u5316\u306f\u3001p53\u907a\u4f1d\u5b50\u5c0e\u5165\u6a39\u72b6\u7d30\u80de\u30ef\u30af\u30c1\u30f3\u306e\u6297\u816b\u760d\u514d\u75ab\u3092\u5897\u5f37\u3059\u308b"},"content":{"rendered":"<p>\u3053\u3093\u306b\u3061\u306f\u3001\u30b7\u30a8\u30f3\uff08<strong><a href=\"https:\/\/x.com\/M12n08Jp\" target=\"_blank\" rel=\"nofollow noopener\">@M12n08Jp<\/a><\/strong>)\u3067\u3059\u3002<\/p>\n<p>\u30aa\u30f3\u30b3\u30ea\u30b9\u306e\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\u304cNature\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u8ad6\u6587\u30da\u30fc\u30b8\uff08\u539f\u6587\uff1a\u82f1\u8a9e\uff09\u2192 https:\/\/www.nature.com\/articles\/s41541-025-01219-5<\/p>\n<div style=\"padding: 16px; border: solid 3px #9f9f9f; border-radius: 5px; background-color: #fff0f5; margin-top: 30px; margin-bottom: 30px;\"><strong>\u3010\u65e2\u5b58\u7642\u6cd5\u3068\u306e\u6bd4\u8f03\u3068OBP-702\u306e\u5229\u70b9\u3011<\/strong>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u3082\u3001Ad-p53 DC\u30ef\u30af\u30c1\u30f3\u306fp53\u767a\u73fe\u816b\u760d\u3092\u6a19\u7684\u3068\u3059\u308bCTL\u3092\u8a98\u5c0e\u3067\u304d\u308b\u6709\u671b\u306a\u6226\u7565\u3067\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u2075\u3002 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DC\u307e\u305f\u306fp53MVA DC\u3092\u7528\u3044\u305f\u514d\u75ab\u7642\u6cd5\u306f\u3001\u524d\u81e8\u5e8a\u304a\u3088\u3073\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066p53\u7279\u7570\u7684\u306aCTL\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u2075\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u91ce\u751f\u578bp53\u3092\u6a19\u7684\u3068\u3059\u308bDC\u30ef\u30af\u30c1\u30f3\u7642\u6cd5\u306e\u6297\u816b\u760d\u52b9\u679c\u306f\u3001\u4ee5\u4e0b\u306e\u8981\u56e0\u306b\u3088\u3063\u3066\u5236\u9650\u3055\u308c\u3066\u3044\u307e\u3059\uff1a<\/p>\n<ul data-start=\"828\" data-end=\"896\">\n<li data-start=\"828\" data-end=\"851\">\n<p data-start=\"830\" data-end=\"851\">\u816b\u760d\u7d30\u80de\u306b\u304a\u3051\u308bp53\u306e\u514d\u75ab\u539f\u6027\u306e\u5f31\u3055<\/p>\n<\/li>\n<li data-start=\"852\" data-end=\"873\">\n<p data-start=\"854\" data-end=\"873\">CTL\u306e\u816b\u760d\u6d78\u6f64\u304c\u4e0d\u5341\u5206\u3067\u3042\u308b\u3053\u3068<\/p>\n<\/li>\n<li data-start=\"874\" data-end=\"896\">\n<p data-start=\"876\" data-end=\"896\">\u514d\u75ab\u6291\u5236\u7684\u306a\u816b\u760d\u5fae\u5c0f\u74b0\u5883\uff08TME\uff09\u306e\u5b58\u5728<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"898\" data-end=\"991\">\u3057\u305f\u304c\u3063\u3066\u3001\u816b\u760d\u7d30\u80de\u5185\u3067p53\u306e\u514d\u75ab\u539f\u6027\u3092\u6d3b\u6027\u5316\u3057\u3001CTL\u306e\u816b\u760d\u6d78\u6f64\u3092\u4fc3\u9032\u3059\u308b\u65b0\u3057\u3044\u6297\u816b\u760d\u30e2\u30c0\u30ea\u30c6\u30a3\u306e\u958b\u767a\u304c\u3001p53\u6a19\u7684DC\u30ef\u30af\u30c1\u30f3\u7642\u6cd5\u306e\u6297\u816b\u760d\u52b9\u679c\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306b\u5fc5\u8981\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p data-start=\"898\" data-end=\"991\">\u00a0<\/p>\n<h2 data-start=\"82\" data-end=\"103\">\u816b\u760d\u6eb6\u89e3\u6027\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\u3068\u672c\u7814\u7a76\u306e\u76ee\u7684<\/h2>\n<p data-start=\"105\" data-end=\"167\">\u816b\u760d\u6eb6\u89e3\u6027\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\u306f\u3001\u5316\u5b66\u7642\u6cd5\u3001\u653e\u5c04\u7dda\u7642\u6cd5\u3001\u514d\u75ab\u7642\u6cd5\u3068\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u65b0\u305f\u306a\u6297\u816b\u760d\u30e2\u30c0\u30ea\u30c6\u30a3\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u2076\u2077\u3002<\/p>\n<p data-start=\"169\" data-end=\"313\">\u6211\u3005\u306f\u3001\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u7279\u7570\u7684\u3067\u8907\u88fd\u80fd\u3092\u6301\u3064\u816b\u760d\u6eb6\u89e3\u6027\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u300cOBP-301\uff08\u30b9\u30e9\u30bf\u30c7\u30ce\u30c1\u30e5\u30ec\u30d6\uff09\u300d\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u2078\u3002OBP-301\u306f\u3001\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u6d3b\u6027\u3092\u6709\u3059\u308b\u60aa\u6027\u816b\u760d\u7d30\u80de\u306b\u5bfe\u3057\u3066\u5e45\u5e83\u3044\u6297\u816b\u760d\u6d3b\u6027\u3092\u793a\u3057\u307e\u3059\u2079\u3002\u307e\u305f\u3001OBP-301\u306f\u4ee5\u4e0b\u306e\u6cbb\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u3092\u6301\u3061\u307e\u3059\uff1a<\/p>\n<ul data-start=\"315\" data-end=\"361\">\n<li data-start=\"315\" data-end=\"325\">\n<p data-start=\"317\" data-end=\"325\">\u5316\u5b66\u7642\u6cd5\u00b9\u2070<\/p>\n<\/li>\n<li data-start=\"326\" data-end=\"337\">\n<p data-start=\"328\" data-end=\"337\">\u653e\u5c04\u7dda\u7642\u6cd5\u00b9\u00b9<\/p>\n<\/li>\n<li data-start=\"338\" data-end=\"361\">\n<p data-start=\"340\" data-end=\"361\">\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\uff08ICIs\uff09\u00b9\u00b2<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"363\" data-end=\"533\">\u3055\u3089\u306b\u3001\u6211\u3005\u306fOBP-301\u306e\u6cbb\u7642\u52b9\u679c\u3092\u9ad8\u3081\u308b\u76ee\u7684\u3067\u3001\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50p53\u3092\u767a\u73fe\u3055\u305b\u308bp53\u5c0e\u5165\u578b\u30a6\u30a4\u30eb\u30b9\u300cOBP-702\u300d\u3092\u65b0\u305f\u306b\u4f5c\u88fd\u3057\u307e\u3057\u305f\u00b9\u00b3\u3002OBP-702\u306f\u3001p53\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066\u3001\u975e\u5c0e\u5165\u578b\u306eOBP-301\u3088\u308a\u3082\u5f37\u3044\u6297\u816b\u760d\u52b9\u679c\u3092\u767a\u63ee\u3057\u3001\u816b\u760d\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08\u7d30\u80de\u6b7b\uff09\u304a\u3088\u3073\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\uff08\u81ea\u5df1\u878d\u89e3\uff09\u3092\u8a98\u5c0e\u3057\u307e\u3059\u00b9\u2074\u3002<\/p>\n<p data-start=\"535\" data-end=\"715\">OBP-702\u306b\u3088\u308bp53\u904e\u5270\u767a\u73fe\u306f\u3001\u30de\u30a6\u30b9\u816b\u760d\u7d30\u80de\u306b\u304a\u3044\u3066\u514d\u75ab\u539f\u6027\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3057\u3001CD8+ CTL\u306e\u816b\u760d\u6d78\u6f64\u3092\u4fc3\u9032\u3057\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\u306e\u6297\u816b\u760d\u52b9\u679c\u3092\u5897\u5f37\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u00b9\u2075\u3002\u307e\u305f\u3001OBP-702\u306f\u3001\u5316\u5b66\u7642\u6cd5\u306b\u62b5\u6297\u6027\u3092\u793a\u3059\u30de\u30a6\u30b9\u81b5\u81d3\u304c\u3093\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001\u514d\u75ab\u6291\u5236\u6027\u306e\u9aa8\u9ac4\u7531\u6765\u6291\u5236\u7d30\u80de\uff08MDSCs\uff09\u306e\u816b\u760d\u6d78\u6f64\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u00b9\u2076\u3002<\/p>\n<p data-start=\"717\" data-end=\"785\">\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001OBP-702\u304c\u816b\u760d\u7d30\u80de\u306b\u304a\u3051\u308bp53\u767a\u73fe\u3092\u6d3b\u6027\u5316\u3057\u3001CTL\u306e\u816b\u760d\u6d78\u6f64\u3092\u4fc3\u9032\u3059\u308b\u6cbb\u7642\u7684\u53ef\u80fd\u6027\u3092\u6301\u3064\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3 data-start=\"787\" data-end=\"797\">\u672c\u7814\u7a76\u306e\u4eee\u8aac<\/h3>\n<p data-start=\"799\" data-end=\"895\">\u305d\u3053\u3067\u6211\u3005\u306f\u3001OBP-702\u3068\u306e\u4f75\u7528\u6cbb\u7642\u306b\u3088\u308a\u3001\u816b\u760d\u7d30\u80de\u5185\u306ep53\u514d\u75ab\u539f\u6027\u304c\u6d3b\u6027\u5316\u3055\u308c\u3001CTL\u306e\u816b\u760d\u6d78\u6f64\u304c\u4fc3\u9032\u3055\u308c\u308b\u3053\u3068\u3067\u3001Ad-p53 DC\u30ef\u30af\u30c1\u30f3\u7642\u6cd5\u306e\u6297\u816b\u760d\u52b9\u679c\u304c\u5411\u4e0a\u3059\u308b\u3068\u4eee\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n<h3 data-start=\"902\" data-end=\"912\">\u672c\u7814\u7a76\u306e\u76ee\u7684<\/h3>\n<p data-start=\"914\" data-end=\"991\">\u672c\u7814\u7a76\u3067\u306f\u3001\u30de\u30a6\u30b9\u5927\u8178\u304c\u3093\uff08colon cancer, CC\uff09\u816b\u760d\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001Ad-p53 DCs\u3068OBP-702\u306e\u4f75\u7528\u52b9\u679c\u3092\u4ee5\u4e0b\u306e\u70b9\u3067\u691c\u8a0e\u3057\u307e\u3057\u305f\uff1a<\/p>\n<ul data-start=\"993\" data-end=\"1208\">\n<li data-start=\"993\" data-end=\"1032\">\n<p data-start=\"995\" data-end=\"1032\">\u4f7f\u7528\u30e2\u30c7\u30eb\uff1aCT26\uff08p53\u91ce\u751f\u578b\uff09\u304a\u3088\u3073MC38\uff08p53\u5909\u7570\u578b\uff09\u7d30\u80de<\/p>\n<\/li>\n<li data-start=\"1033\" data-end=\"1061\">\n<p data-start=\"1035\" data-end=\"1061\">DC\u6210\u719f\u30de\u30fc\u30ab\u30fc\u306e\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u306b\u3088\u308b\u89e3\u6790<\/p>\n<\/li>\n<li data-start=\"1062\" data-end=\"1106\">\n<p data-start=\"1064\" data-end=\"1106\">\u5358\u5074\u304a\u3088\u3073\u4e21\u5074\u306e\u76ae\u4e0bCC\u816b\u760d\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u6cbb\u7642\u52b9\u679c\u3068\u816b\u760d\u5fae\u5c0f\u74b0\u5883\uff08TME\uff09\u306e\u5909\u5316<\/p>\n<\/li>\n<li data-start=\"1107\" data-end=\"1172\">\n<p data-start=\"1109\" data-end=\"1172\">Ad-p53 DC\u304a\u3088\u3073OBP-702\u51e6\u7406\u816b\u760d\u7d30\u80de\u306b\u304a\u3051\u308bMHC\u5206\u5b50\u3092\u4ecb\u3057\u305fp53\u30a8\u30d4\u30c8\u30fc\u30d7\u63d0\u793a\u306e\u514d\u75ab\u30da\u30d7\u30c1\u30c9\u30aa\u30df\u30af\u30b9\u89e3\u6790<\/p>\n<\/li>\n<li data-start=\"1173\" data-end=\"1208\">\n<p data-start=\"1175\" data-end=\"1208\">OBP-702\u51e6\u7406\u816b\u760d\u7d30\u80de\u306b\u304a\u3051\u308bp53\u30a8\u30d4\u30c8\u30fc\u30d7\u5fdc\u7b54CTL\u306e\u89e3\u6790<\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"55\" data-end=\"62\">\u7d50\u679c<\/h2>\n<h3 data-start=\"63\" data-end=\"114\">Ad-p53 DCs\u306e\u7279\u6027\u8a55\u4fa1\uff08Characterization of Ad-p53 DCs\uff09<\/h3>\n<p data-start=\"116\" data-end=\"265\">Ad-p53 DCs\u3092\u5f97\u308b\u305f\u3081\u306b\u3001C57BL\/6J\u30de\u30a6\u30b9\u306e\u5927\u817f\u9aa8\u304b\u3089\u5206\u96e2\u3057\u305f\u9aa8\u9ac4\u7531\u6765\u6a39\u72b6\u7d30\u80de\uff08BMDCs\uff09\u3092\u3001GM-CSF\uff08\u9846\u7c92\u7403\u30fb\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u30b3\u30ed\u30cb\u30fc\u523a\u6fc0\u56e0\u5b50\uff09\u304a\u3088\u3073IL-4\uff08\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-4\uff09\u3068\u5171\u306b5\u65e5\u9593\u57f9\u990a\u3057\u3001\u305d\u306e\u5f8c\u3001\u8907\u88fd\u4e0d\u80fd\u306aAd-p53\u30672\u65e5\u9593\u611f\u67d3\u3055\u305b\u307e\u3057\u305f\uff08\u56f31A\u3001\u88dc\u8db3\u56f31A\uff09\u3002<\/p>\n<p data-start=\"267\" data-end=\"329\">\u5bfe\u7167\u3068\u3057\u3066\u3001E1A\u9818\u57df\u3092\u6b20\u640d\u3057\u305f\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9DL312\uff08\u88dc\u8db3\u56f31B\uff09\u3067\u611f\u67d3\u3055\u305b\u305fDC\uff08DL312 DCs\uff09\u3082\u7528\u610f\u3057\u307e\u3057\u305f\u3002<\/p>\n<p data-start=\"331\" data-end=\"483\"><strong data-start=\"331\" data-end=\"346\">\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR\u89e3\u6790<\/strong>\u3067\u306f\u3001\u5bfe\u7167DC\u3084DL312 DCs\u3068\u6bd4\u3079\u3066\u3001Ad-p53 DCs\u3067\u30d2\u30c8p53 mRNA\u306e\u767a\u73fe\u304c\u6709\u610f\u306b\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08\u56f31B\u3001\u88dc\u8db3\u56f32\uff09\u3002<br data-start=\"422\" data-end=\"425\" \/><br \/>\n<strong data-start=\"425\" data-end=\"437\">\u514d\u75ab\u7d30\u80de\u5316\u5b66\u89e3\u6790<\/strong>\u3067\u3082\u3001Ad-p53\u3067\u611f\u67d3\u3055\u305b\u305fDC\u5185\u306b\u30d2\u30c8p53\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff08\u56f31C\uff09\u3002<\/p>\n<p data-start=\"485\" data-end=\"561\">\u3055\u3089\u306b\u3001Ad-p53 DCs\u306e\u6210\u719f\u5ea6\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u3001CD11c+ DC\u306b\u304a\u3051\u308b\u4ee5\u4e0b\u306e\u30de\u30fc\u30ab\u30fc\u306e\u767a\u73fe\u3092\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u306b\u3088\u308a\u89e3\u6790\u3057\u307e\u3057\u305f\uff08\u88dc\u8db3\u56f33\uff09\uff1a<\/p>\n<ul data-start=\"563\" data-end=\"623\">\n<li data-start=\"563\" data-end=\"605\">\n<p data-start=\"565\" data-end=\"605\">DC\u6210\u719f\u30de\u30fc\u30ab\u30fc\uff1aCD86, MHC\u30af\u30e9\u30b9II\uff08MHC-II\uff09, CD103<\/p>\n<\/li>\n<li data-start=\"606\" data-end=\"623\">\n<p data-start=\"608\" data-end=\"623\">DC\u79fb\u52d5\u30de\u30fc\u30ab\u30fc\uff1aCCR7<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"625\" data-end=\"765\">\u305d\u306e\u7d50\u679c\u3001Ad-p53 DCs\u304a\u3088\u3073DL312 DCs\u306f\u3001\u5bfe\u7167DC\u3068\u6bd4\u8f03\u3057\u3066\u3001\u4e0a\u8a18\u30de\u30fc\u30ab\u30fc\u3092\u767a\u73fe\u3059\u308bCD11c+ DC\u306e\u5272\u5408\u304c\u6709\u610f\u306b\u9ad8\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\uff08\u56f31D\uff09\u3002<br data-start=\"708\" data-end=\"711\" \/><br \/>\n\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001Ad-p53 DCs\u306f\u30d2\u30c8p53\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u73fe\u3059\u308b\u6210\u719f\u3057\u305fDC\u3092\u542b\u3080\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3 data-start=\"43\" data-end=\"114\">\u30a6\u30a4\u30eb\u30b9\u5c0e\u5165DC\u306e\u30ea\u30f3\u30d1\u7bc0\u3078\u306e\u79fb\u884c\uff08Migration of virus-transduced DCs to lymph nodes\uff09<\/h3>\n<p data-start=\"116\" data-end=\"310\">\u6a39\u72b6\u7d30\u80de\uff08DC\uff09\u306f\u3001\u5c40\u6240\u30ea\u30f3\u30d1\u7bc0\uff08LNs\uff09\u306b\u304a\u3044\u3066T\u7d30\u80de\u3078\u816b\u760d\u95a2\u9023\u6297\u539f\uff08TAA\uff09\u3092\u63d0\u793a\u3059\u308b\u4e0a\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u00b9\u2077\u3002<br data-start=\"178\" data-end=\"181\" \/><br \/>\n\u672c\u7814\u7a76\u3067\u306f\u3001\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u3067\u5c0e\u5165\u3057\u305fDC\u304c\u5c40\u6240\u30ea\u30f3\u30d1\u7bc0\u3078\u79fb\u884c\u53ef\u80fd\u304b\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u3001\u7dd1\u8272\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\uff08GFP\uff09\u3092\u767a\u73fe\u3059\u308b\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\uff08Ad-GFP\uff09\u3067\u611f\u67d3\u3055\u305b\u305fDC\uff08Ad-GFP DCs\uff09\u3092\u30de\u30a6\u30b9\u306e\u5de6\u8db3\u5e95\u306b\u6ce8\u5c04\u3057\u300124\u6642\u9593\u5f8c\u306b\u5de6\u9f20\u5f84\u30ea\u30f3\u30d1\u7bc0\u3092\u6458\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n<p data-start=\"312\" data-end=\"419\">\u305d\u306e\u7d50\u679c\u3001Ad-GFP DCs\u3092\u63a5\u7a2e\u3057\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u6458\u51fa\u3057\u305f\u30ea\u30f3\u30d1\u7bc0\u306b\u304a\u3044\u3066GFP\u306e\u86cd\u5149\u30b7\u30b0\u30ca\u30eb\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff08\u88dc\u8db3\u56f34\uff09\u3002<br data-start=\"375\" data-end=\"378\" \/><br \/>\n\u3053\u308c\u306b\u3088\u308a\u3001\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u611f\u67d3DC\u306f\u5c40\u6240\u30ea\u30f3\u30d1\u7bc0\u3078\u79fb\u884c\u3067\u304d\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<hr data-start=\"421\" data-end=\"424\" \/>\n<h3 data-start=\"426\" data-end=\"481\">Ad-p53 DCs\u3068OBP-702\u4f75\u7528\u7642\u6cd5\u306ep53\u91ce\u751f\u578bCT26\u816b\u760d\u306b\u304a\u3051\u308bin vivo\u6297\u816b\u760d\u52b9\u679c<\/h3>\n<p data-start=\"483\" data-end=\"774\">\u4f75\u7528\u7642\u6cd5\u306e\u6cbb\u7642\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u3001p53\u91ce\u751f\u578b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f4e\u767a\u73fe\u3059\u308bCT26\u5927\u8178\u304c\u3093\u7d30\u80de\u682a\u3092\u7528\u3044\u307e\u3057\u305f\u00b9\u2078\u3002<br data-start=\"537\" data-end=\"540\" \/><br \/>\n\u307e\u305a\u3001CT26\u7d30\u80de\u306bOBP-702\u309272\u6642\u9593\u611f\u67d3\u3055\u305b\u305f\u3068\u3053\u308d\u3001\u7d30\u80de\u751f\u5b58\u7387\u306f\u7528\u91cf\u4f9d\u5b58\u7684\u306b\u4f4e\u4e0b\u3057\u307e\u3057\u305f\uff08\u56f32A\uff09\u3002<br data-start=\"595\" data-end=\"598\" \/><br \/>\n\u6b21\u306b\u3001OBP-702\u306724\u6642\u9593\u304a\u3088\u307372\u6642\u9593\u611f\u67d3\u3055\u305b\u305fCT26\u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0RT-PCR\u3068\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u89e3\u6790\u3092\u7528\u3044\u3066\u3001\u30d2\u30c8p53 mRNA\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff08\u56f32B\u30fbC\u3001\u88dc\u8db3\u56f35\uff09\u3002<br data-start=\"707\" data-end=\"710\" \/><br \/>\n\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001CT26\u7d30\u80de\u304cOBP-702\u306b\u3088\u308b\u30a6\u30a4\u30eb\u30b9\u6027\u7d30\u80de\u50b7\u5bb3\u4f5c\u7528\u304a\u3088\u3073p53\u6d3b\u6027\u5316\u306b\u5bfe\u3057\u3066\u611f\u53d7\u6027\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3059\u3002<\/p>\n<h4 data-start=\"776\" data-end=\"791\">in vivo\u8a66\u9a13\uff1a<\/h4>\n<p data-start=\"793\" data-end=\"947\">p53\u91ce\u751f\u578bCT26\u7d30\u80de\u306b\u3088\u308b\u76ae\u4e0b\u816b\u760d\u30e2\u30c7\u30eb\u3092\u30de\u30a6\u30b9\u306b\u4f5c\u88fd\u3057\u3001\u4f75\u7528\u7642\u6cd5\u306e\u6cbb\u7642\u52b9\u679c\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002<br data-start=\"841\" data-end=\"844\" \/><br \/>\n\u904e\u53bb\u306e\u7814\u7a76\u3067\u3001Ad-p53 DC\u306b\u3088\u308b2\u56de\u306e\u514d\u75ab\u63a5\u7a2e\u304c\u52b9\u679c\u7684\u306b\u6297p53\u514d\u75ab\u5fdc\u7b54\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u00b9\u2079\u3002<br data-start=\"901\" data-end=\"904\" \/><br \/>\n\u305d\u3053\u3067\u672c\u7814\u7a76\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u3067Ad-p53 DCs\u3092\u30de\u30a6\u30b9\u306b\u76ae\u4e0b\u6ce8\u5c04\u3057\u307e\u3057\u305f\uff1a<\/p>\n<ul data-start=\"949\" data-end=\"984\">\n<li data-start=\"949\" data-end=\"972\">\n<p data-start=\"951\" data-end=\"972\">\u816b\u760d\u63a5\u7a2e\u524d\uff1a\u221221\u65e5\u3001\u221214\u65e5\u3001\u22127\u65e5<\/p>\n<\/li>\n<li data-start=\"973\" data-end=\"984\">\n<p data-start=\"975\" data-end=\"984\">\u816b\u760d\u63a5\u7a2e\u5f8c\uff1a+6\u65e5<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"986\" data-end=\"1150\">CT26\u816b\u760d\u3092\u63a5\u7a2e\u3057\u305f\u30de\u30a6\u30b9\u306b\u306f\u3001\u816b\u760d\u63a5\u7a2e\u304b\u30897\u65e5\u76ee\u304a\u3088\u307310\u65e5\u76ee\u306bOBP-702\u3092\u816b\u760d\u5185\u6ce8\u5c04\u3057\u307e\u3057\u305f\uff08\u56f32D\uff09\u3002<br data-start=\"1043\" data-end=\"1046\" \/><br \/>\n\u305d\u306e\u7d50\u679c\u3001Ad-p53 DCs\u3068OBP-702\u306e\u4f75\u7528\u7642\u6cd5\u306f\u3001\u5bfe\u7167\u7fa4\u304a\u3088\u3073\u5358\u5264\u6cbb\u7642\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u816b\u760d\u306e\u5897\u6b96\u3092\u6709\u610f\u306b\u6291\u5236\u3057\u307e\u3057\u305f\uff08\u56f32E\u30fbF\uff09\u3002<br data-start=\"1116\" data-end=\"1119\" \/><br \/>\n\u307e\u305f\u3001\u6458\u51fa\u816b\u760d\u306e\u91cd\u91cf\u3082\u4f75\u7528\u7fa4\u3067\u6709\u610f\u306b\u8efd\u304f\u306a\u308a\u307e\u3057\u305f\uff08\u56f32G\uff09\u3002<\/p>\n<p data-start=\"1152\" data-end=\"1211\">\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\u3001<strong data-start=\"1160\" data-end=\"1211\">OBP-702\u3068\u306e\u4f75\u7528\u306f\u3001Ad-p53 DCs\u306e\u6297\u816b\u760d\u52b9\u679c\u3092\u8457\u3057\u304f\u5897\u5f37\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/strong><\/p>\n<h3 data-start=\"56\" data-end=\"106\">Ad-p53 DCs\u3068OBP-702\u306e\u4f75\u7528\u306b\u3088\u308bCT26\u816b\u760d\u306b\u304a\u3051\u308b\u6297\u816b\u760d\u514d\u75ab\u5fdc\u7b54\u306e\u5897\u5f37<\/h3>\n<p data-start=\"107\" data-end=\"204\">\uff08Enhancement of the antitumor immune response in CT26 tumors treated with Ad-p53 DCs and OBP-702\uff09<\/p>\n<p data-start=\"206\" data-end=\"315\">\u4f75\u7528\u7642\u6cd5\u304c\u816b\u760d\u5fae\u5c0f\u74b0\u5883\uff08TME\uff09\u306b\u304a\u3051\u308b\u514d\u75ab\u72b6\u614b\u3092\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3055\u305b\u308b\u304b\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u3001CD8\u207aT\u7d30\u80de\u304a\u3088\u3073CD11c\u207a\u6a39\u72b6\u7d30\u80de\uff08DC\uff09\u306e\u5272\u5408\u3092\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u304a\u3088\u3073\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u3067\u89e3\u6790\u3057\u307e\u3057\u305f\uff08\u88dc\u8db3\u56f36\u304a\u3088\u30737\uff09\u3002<\/p>\n<p data-start=\"317\" data-end=\"401\"><strong data-start=\"317\" data-end=\"332\">\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u89e3\u6790\u306e\u7d50\u679c<\/strong>\u3001CD8\u207aT\u7d30\u80de\u304a\u3088\u3073CD11c\u207aDC\u306e\u6570\u306f\u3001\u4f75\u7528\u7642\u6cd5\u3092\u53d7\u3051\u305f\u816b\u760d\u3067\u3001\u5bfe\u7167\u7fa4\u3084\u5358\u5264\u6cbb\u7642\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u591a\u304f\u306a\u3063\u3066\u3044\u307e\u3057\u305f\uff08\u56f33A\u30fbB\uff09\u3002<\/p>\n<p data-start=\"403\" data-end=\"493\"><strong data-start=\"403\" data-end=\"419\">\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u89e3\u6790<\/strong>\u306b\u304a\u3044\u3066\u3082\u3001\u4f75\u7528\u7642\u6cd5\u3092\u65bd\u3057\u305f\u816b\u760d\u306f\u3001\u5bfe\u7167\u304a\u3088\u3073\u5358\u5264\u6cbb\u7642\u7fa4\u3088\u308a\u3082CD8\u207aCTL\u304a\u3088\u3073CD11c\u207aDC\u306e\u5272\u5408\u304c\u6709\u610f\u306b\u9ad8\u3044\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff08\u56f33C\uff09\u3002<\/p>\n<p data-start=\"495\" data-end=\"528\">\u3055\u3089\u306b\u3001\u4ee5\u4e0b\u306e\u6d3b\u6027\u5316\u30de\u30fc\u30ab\u30fc\u3092\u767a\u73fe\u3059\u308bT\u7d30\u80de\u306e\u5272\u5408\u3082\u8a55\u4fa1\u3057\u307e\u3057\u305f\uff1a<\/p>\n<ul data-start=\"530\" data-end=\"618\">\n<li data-start=\"530\" data-end=\"560\">\n<p data-start=\"532\" data-end=\"560\">CD8\u207aCD137\u207a\uff08\u6297\u539f\u7279\u7570\u7684T\u7d30\u80de\u30de\u30fc\u30ab\u30fc\uff09\u00b2\u2070<\/p>\n<\/li>\n<li data-start=\"561\" data-end=\"589\">\n<p data-start=\"563\" data-end=\"589\">CD8\u207aCD69\u207a\uff08\u30e1\u30e2\u30ea\u30fcT\u7d30\u80de\u30de\u30fc\u30ab\u30fc\uff09\u00b2\u00b9<\/p>\n<\/li>\n<li data-start=\"590\" data-end=\"618\">\n<p data-start=\"592\" data-end=\"618\">CD8\u207aPD-1\u207a\uff08\u6297\u539f\u8a8d\u8b58\u4e2d\u306eT\u7d30\u80de\u30de\u30fc\u30ab\u30fc\uff09\u00b2\u00b2<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"620\" data-end=\"685\">\u305d\u306e\u7d50\u679c\u3001\u4f75\u7528\u7642\u6cd5\u7fa4\u3067\u306f\u3053\u308c\u3089\u306e\u30de\u30fc\u30ab\u30fc\u3092\u767a\u73fe\u3059\u308bT\u7d30\u80de\u306e\u5272\u5408\u3082\u3001\u5bfe\u7167\u304a\u3088\u3073\u5358\u5264\u6cbb\u7642\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u56f33C\uff09\u3002<\/p>\n<p data-start=\"687\" data-end=\"767\">\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u3001<strong data-start=\"696\" data-end=\"767\">OBP-702\u3068\u306e\u4f75\u7528\u304cAd-p53 DCs\u306b\u3088\u308b\u6297\u816b\u760d\u52b9\u679c\u3092\u5897\u5f37\u3057\u3001CD8\u207aCTL\u304a\u3088\u3073DC\u306e\u816b\u760d\u6d78\u6f64\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/strong><\/p>\n<p data-start=\"1152\" data-end=\"1211\">\u00a0<\/p>\n<h3 data-start=\"45\" data-end=\"100\">OBP-702\u306fT\u7d30\u80de\u4f9d\u5b58\u6027\u306e\u6297\u816b\u760d\u514d\u75ab\u5fdc\u7b54\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3067Ad-p53 DCs\u306e\u52b9\u679c\u3092\u5897\u5f37\u3059\u308b<\/h3>\n<p data-start=\"101\" data-end=\"204\">\uff08OBP-702 enhances the antitumor efficacy of Ad-p53 DCs via activation of the antitumor immune response\uff09<\/p>\n<p data-start=\"206\" data-end=\"371\">\u307e\u305a\u3001\u4f75\u7528\u7642\u6cd5\u306b\u304a\u3051\u308bT\u7d30\u80de\u306e\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u3001T\u7d30\u80de\u3092\u6b20\u640d\u3057\u3066\u3044\u308b<strong data-start=\"243\" data-end=\"253\">\u30cc\u30fc\u30c9\u30de\u30a6\u30b9<\/strong>\uff08athymic nude mice\uff09\u3092\u7528\u3044\u3066\u540c\u69d8\u306e\u6cbb\u7642\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001Ad-p53 DCs\uff0bOBP-702\u306e\u4f75\u7528\u52b9\u679c\u306f\u5927\u5e45\u306b\u4f4e\u4e0b\u3057\u307e\u3057\u305f\uff08\u56f34A\uff09\u3002<br data-start=\"328\" data-end=\"331\" \/><br \/>\n\u3053\u306e\u7d50\u679c\u306f\u3001T\u7d30\u80de\u304c\u4f75\u7528\u7642\u6cd5\u306b\u304a\u3051\u308b\u6297\u816b\u760d\u52b9\u679c\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p data-start=\"373\" data-end=\"594\">\u307e\u305f\u3001\u4f75\u7528\u7642\u6cd5\u306b\u304a\u3044\u3066<strong data-start=\"384\" data-end=\"403\">p53\u6a19\u7684\u306eCTL\u304c\u679c\u305f\u3059\u5f79\u5272<\/strong>\u3092\u8abf\u3079\u308b\u305f\u3081\u3001p53\u3092\u5c0e\u5165\u3057\u3066\u3044\u306a\u3044\u816b\u760d\u6eb6\u89e3\u6027\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\uff08OBP-301\uff09\u3092\u7528\u3044\u3066\u3001Ad-p53 DC\u30ef\u30af\u30c1\u30f3\u3068\u306e\u4f75\u7528\u52b9\u679c\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002<br data-start=\"474\" data-end=\"477\" \/><br \/>\n\u3057\u304b\u3057\u3001OBP-301\u3068\u306e\u4f75\u7528\u3067\u306f\u6297\u816b\u760d\u52b9\u679c\u306e\u5897\u5f37\u306f\u307f\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u56f34B\uff09\u3002<br data-start=\"518\" data-end=\"521\" \/><br \/>\n\u3053\u308c\u306b\u3088\u308a\u3001OBP-702\u306b\u3088\u308b\u816b\u760d\u7d30\u80de\u5185p53\u306e\u6d3b\u6027\u5316\u304c\u3001Ad-p53 DC\u306b\u3088\u308bp53\u6a19\u7684CTL\u8a98\u5c0e\u306e\u52b9\u679c\u3092\u9ad8\u3081\u308b\u9375\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<hr data-start=\"596\" data-end=\"599\" \/>\n<h3 data-start=\"601\" data-end=\"632\">\u4f75\u7528\u7642\u6cd5\u306b\u3088\u3063\u3066\u9577\u671f\u7684\u306a\u5168\u8eab\u6297\u816b\u760d\u514d\u75ab\u304c\u8a98\u5c0e\u3055\u308c\u308b<\/h3>\n<p data-start=\"633\" data-end=\"690\">\uff08Combination therapy induces systemic antitumor immunity\uff09<\/p>\n<p data-start=\"692\" data-end=\"768\">\u4f75\u7528\u7642\u6cd5\u306b\u3088\u308a\u5b8c\u5168\u594f\u52b9\uff08CR\uff09\u3092\u793a\u3057\u305f\u30de\u30a6\u30b93\u5339\u3068\u3001\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u5bfe\u7167\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u3001\u518d\u6311\u6226\u8a66\u9a13\uff08rechallenge test\uff09\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002<\/p>\n<p data-start=\"770\" data-end=\"818\">\u53f3\u5074\u80cc\u90e8\u306b\u306fCT26\u7d30\u80de\uff08\u5143\u306e\u304c\u3093\u7d30\u80de\u682a\uff09\u3001\u5de6\u5074\u80cc\u90e8\u306b\u306f4T1\u4e73\u304c\u3093\u7d30\u80de\u3092\u540c\u6642\u306b\u63a5\u7a2e\u3057\u305f\u3068\u3053\u308d\uff1a<\/p>\n<ul data-start=\"820\" data-end=\"911\">\n<li data-start=\"820\" data-end=\"874\">\n<p data-start=\"822\" data-end=\"874\"><strong data-start=\"822\" data-end=\"832\">CT26\u7d30\u80de<\/strong>\u306f\u3001\u5bfe\u7167\u30de\u30a6\u30b9\u3067\u306f\u816b\u760d\u5f62\u6210\u3057\u305f\u304c\u3001CR\u30de\u30a6\u30b9\u3067\u306f\u816b\u760d\u5f62\u6210\u3057\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u56f34C\uff09<\/p>\n<\/li>\n<li data-start=\"875\" data-end=\"911\">\n<p data-start=\"877\" data-end=\"911\"><strong data-start=\"877\" data-end=\"886\">4T1\u7d30\u80de<\/strong>\u306f\u3001\u4e21\u7fa4\u3067\u540c\u7a0b\u5ea6\u306e\u816b\u760d\u5f62\u6210\u3092\u793a\u3057\u307e\u3057\u305f\uff08\u88dc\u8db3\u56f38\uff09<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"913\" data-end=\"969\">\u3053\u306e\u7d50\u679c\u304b\u3089\u3001<strong data-start=\"920\" data-end=\"959\">\u4f75\u7528\u7642\u6cd5\u306b\u3088\u308aCT26\u306b\u5bfe\u3059\u308b\u9577\u671f\u7684\u304b\u3064\u7279\u7570\u7684\u306a\u6297\u816b\u760d\u514d\u75ab\u304c\u5f62\u6210\u3055\u308c\u305f<\/strong>\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n<hr data-start=\"971\" data-end=\"974\" \/>\n<h3 data-start=\"976\" data-end=\"1010\">\u30a2\u30d6\u30b9\u30b3\u30d1\u30eb\u52b9\u679c\uff08abscopal effect\uff09\u306e\u78ba\u8a8d<\/h3>\n<p data-start=\"1011\" data-end=\"1067\">\uff08Systemic antitumor effect observed in untreated tumors\uff09<\/p>\n<p data-start=\"1069\" data-end=\"1142\">\u6b21\u306b\u3001\u4f75\u7528\u7642\u6cd5\u304c\u672a\u6cbb\u7642\u306e\u816b\u760d\u306b\u3082\u6ce2\u53ca\u52b9\u679c\uff08\u30a2\u30d6\u30b9\u30b3\u30d1\u30eb\u52b9\u679c\uff09\u3092\u53ca\u307c\u3059\u304b\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u3001<strong data-start=\"1112\" data-end=\"1129\">\u4e21\u5074\u76ae\u4e0bCT26\u816b\u760d\u30e2\u30c7\u30eb<\/strong>\u3092\u7528\u3044\u307e\u3057\u305f\uff08\u88dc\u8db3\u56f39\uff09\u3002<\/p>\n<ul data-start=\"1144\" data-end=\"1215\">\n<li data-start=\"1144\" data-end=\"1189\">\n<p data-start=\"1146\" data-end=\"1189\">\u4e00\u65b9\u306e\u816b\u760d\u306b\u306f\u3001Ad-p53 DCs\u5358\u72ec\u3001OBP-702\u5358\u72ec\u3001\u307e\u305f\u306f\u4f75\u7528\u7642\u6cd5\u3092\u6295\u4e0e<\/p>\n<\/li>\n<li data-start=\"1190\" data-end=\"1215\">\n<p data-start=\"1192\" data-end=\"1215\">\u3082\u3046\u4e00\u65b9\u306e\u816b\u760d\u306b\u306f\u4e00\u5207\u6cbb\u7642\u3092\u884c\u308f\u306a\u3044\uff08\u672a\u6cbb\u7642\uff09<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1217\" data-end=\"1220\">\u7d50\u679c\uff1a<\/p>\n<ul data-start=\"1222\" data-end=\"1342\">\n<li data-start=\"1222\" data-end=\"1274\">\n<p data-start=\"1224\" data-end=\"1274\"><strong data-start=\"1224\" data-end=\"1232\">\u4f75\u7528\u7642\u6cd5<\/strong>\u306f\u3001\u6cbb\u7642\u5074\u3060\u3051\u3067\u306a\u304f\u3001<strong data-start=\"1243\" data-end=\"1263\">\u672a\u6cbb\u7642\u5074\u306e\u816b\u760d\u306e\u5897\u6b96\u3082\u6709\u610f\u306b\u6291\u5236<\/strong>\u3057\u307e\u3057\u305f\uff08\u56f34D\uff09<\/p>\n<\/li>\n<li data-start=\"1275\" data-end=\"1342\">\n<p data-start=\"1277\" data-end=\"1342\">\u4e00\u65b9\u3001<strong data-start=\"1280\" data-end=\"1306\">Ad-p53 DCs\u5358\u72ec\u3084OBP-702\u5358\u72ec<\/strong>\u3067\u306f\u3001\u6cbb\u7642\u5074\u306e\u816b\u760d\u306f\u6291\u5236\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u672a\u6cbb\u7642\u5074\u306b\u306f\u52b9\u679c\u304c\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1344\" data-end=\"1415\">\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u89e3\u6790\u3067\u306f\u3001\u672a\u6cbb\u7642\u816b\u760d\u306b\u304a\u3044\u3066\u3082<strong data-start=\"1365\" data-end=\"1393\">CD8\u207aT\u7d30\u80de\u304a\u3088\u3073CD11c\u207aDC\u306e\u6d78\u6f64\u304c\u5897\u52a0<\/strong>\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\uff08\u56f34E\u30fbF\uff09\u3002<\/p>\n<p data-start=\"1417\" data-end=\"1494\">\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001<strong data-start=\"1425\" data-end=\"1484\">Ad-p53 DCs\uff0bOBP-702\u306e\u4f75\u7528\u7642\u6cd5\u304c\u5168\u8eab\u7684\u306a\u6297\u816b\u760d\u514d\u75ab\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u30a2\u30d6\u30b9\u30b3\u30d1\u30eb\u52b9\u679c\u3092\u3082\u305f\u3089\u3059<\/strong>\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p data-start=\"1417\" data-end=\"1494\">\u00a0<\/p>\n<h2 data-start=\"31\" data-end=\"83\">Ad-p53 DCs\u304a\u3088\u3073OBP-702\u611f\u67d3\u816b\u760d\u7d30\u80de\u304c\u5171\u901a\u3057\u3066\u63d0\u793a\u3059\u308bp53\u7531\u6765\u30da\u30d7\u30c1\u30c9\u306e\u540c\u5b9a<\/h2>\n<p data-start=\"84\" data-end=\"219\">\uff08Identification of p53-derived peptides commonly bound to MHC molecules on the surfaces of Ad-p53 DCs and OBP-702-infected tumor cells\uff09<\/p>\n<p data-start=\"221\" data-end=\"354\">\u30d2\u30c8\u304a\u3088\u3073\u30de\u30a6\u30b9\u306e\u816b\u760d\u7d30\u80de\u306b\u304a\u3044\u3066\u3001OBP-702\u304cp53\u306e\u904e\u5270\u767a\u73fe\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306f\u3059\u3067\u306b\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u00b9\u00b3,\u00b9\u2075\u3002<br data-start=\"279\" data-end=\"282\" \/><br \/>\n\u3057\u305f\u304c\u3063\u3066\u3001<strong data-start=\"288\" data-end=\"353\">OBP-702\u3067\u611f\u67d3\u3057\u305f\u816b\u760d\u7d30\u80de\u306f\u3001Ad-p53 DC\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u305fCTL\u306b\u5bfe\u3057\u3066\u3088\u308a\u9ad8\u3044\u611f\u53d7\u6027\u3092\u793a\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059<\/strong>\u3002<\/p>\n<p data-start=\"356\" data-end=\"531\">\u3053\u306e\u4eee\u8aac\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001Ad-p53 DCs\u3067\u514d\u75ab\u3055\u308c\u305f\u30de\u30a6\u30b9\u3068\u975e\u514d\u75ab\u30de\u30a6\u30b9\u304b\u3089\u813e\u7d30\u80de\u3092\u63a1\u53d6\u3057\u3001IL-2\u3067\u523a\u6fc0\u3057\u3066CD8\u207aT\u7d30\u80de\u3092\u8a98\u5c0e\u3057\u307e\u3057\u305f\u3002<br data-start=\"429\" data-end=\"432\" \/><br \/>\n\u3053\u308c\u3089\u306eCD8\u207aT\u7d30\u80de\u3092\u3001OBP-702\u611f\u67d3\u7d30\u80de\u307e\u305f\u306f\u975e\u611f\u67d3CT26\u7d30\u80de\u30686\u6642\u9593\u5171\u57f9\u990a\u3057\u305f\u5f8c\u3001IFN-\u03b3\u304a\u3088\u3073\u30b0\u30e9\u30f3\u30b6\u30a4\u30e0B\u3092\u767a\u73fe\u3059\u308bCD8\u207aT\u7d30\u80de\u306e\u5272\u5408\u3092FACS\u89e3\u6790\u3067\u8a55\u4fa1\u3057\u307e\u3057\u305f\uff08\u88dc\u8db3\u56f310\uff09\u3002<\/p>\n<p data-start=\"533\" data-end=\"536\">\u7d50\u679c\uff1a<\/p>\n<ul data-start=\"538\" data-end=\"669\">\n<li data-start=\"538\" data-end=\"627\">\n<p data-start=\"540\" data-end=\"627\"><strong data-start=\"540\" data-end=\"563\">OBP-702\u611f\u67d3CT26\u7d30\u80de\u3068\u5171\u57f9\u990a<\/strong>\u3057\u305f\u5834\u5408\u3001Ad-p53 DC\u514d\u75ab\u30de\u30a6\u30b9\u7531\u6765CD8\u207aT\u7d30\u80de\u306f\u3001IFN-\u03b3\u207a\u304a\u3088\u3073\u30b0\u30e9\u30f3\u30b6\u30a4\u30e0B\u207a\u7d30\u80de\u306e\u5272\u5408\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u307e\u3057\u305f<\/p>\n<\/li>\n<li data-start=\"628\" data-end=\"669\">\n<p data-start=\"630\" data-end=\"669\"><strong data-start=\"630\" data-end=\"648\">\u975e\u611f\u67d3CT26\u7d30\u80de\u3068\u306e\u5171\u57f9\u990a<\/strong>\u3067\u306f\u3053\u306e\u52b9\u679c\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u56f35A\uff09<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"671\" data-end=\"740\">&#x27a1;&#xfe0f; \u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001<strong data-start=\"682\" data-end=\"739\">Ad-p53 DC\u30ef\u30af\u30c1\u30f3\u7642\u6cd5\u304c\u3001OBP-702\u611f\u67d3\u816b\u760d\u7d30\u80de\u3092\u6a19\u7684\u3068\u3059\u308bCTL\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059<\/strong>\u3002<\/p>\n<hr data-start=\"742\" data-end=\"745\" \/>\n<h3 data-start=\"747\" data-end=\"773\">p53\u7531\u6765\u30da\u30d7\u30c1\u30c9\u306e\u514d\u75ab\u30da\u30d7\u30c1\u30c9\u30aa\u30df\u30af\u30b9\u89e3\u6790<\/h3>\n<p data-start=\"775\" data-end=\"857\">Ad-p53 DCs\u306f\u3001MHC-I\u304a\u3088\u3073MHC-II\u306b\u7d50\u5408\u3057\u305fp53\u30da\u30d7\u30c1\u30c9\u3092\u63d0\u793a\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u306b\u3088\u308aCD8\u207a\u304a\u3088\u3073CD4\u207aT\u7d30\u80de\u304c\u8a98\u5c0e\u3055\u308c\u307e\u3059\u00b9\u2079\u3002<\/p>\n<p data-start=\"859\" data-end=\"937\">\u672c\u7814\u7a76\u3067\u306f\u3001**\u514d\u75ab\u30da\u30d7\u30c1\u30c9\u30aa\u30df\u30af\u30b9\uff08immunopeptidomics\uff09**\u306e\u624b\u6cd5\u3092\u7528\u3044\u3066\u3001\u4ee5\u4e0b\u306e\u7d30\u80de\u304b\u3089MHC\u7d50\u5408\u30da\u30d7\u30c1\u30c9\u3092\u5358\u96e2\u30fb\u8cea\u91cf\u5206\u6790\u3057\u307e\u3057\u305f\u00b2\u00b3\uff1a<\/p>\n<ul data-start=\"939\" data-end=\"1063\">\n<li data-start=\"939\" data-end=\"1009\">\n<p data-start=\"941\" data-end=\"1009\">MHC-I\uff1a<br data-start=\"947\" data-end=\"950\" \/><br \/>\n\u3000- \u30b3\u30f3\u30c8\u30ed\u30fc\u30ebCT26\u7d30\u80de<br data-start=\"965\" data-end=\"968\" \/><br \/>\n\u3000- OBP-301\u611f\u67d3CT26\u7d30\u80de<br data-start=\"986\" data-end=\"989\" \/><br \/>\n\u3000- OBP-702\u611f\u67d3CT26\u7d30\u80de<\/p>\n<\/li>\n<li data-start=\"1011\" data-end=\"1063\">\n<p data-start=\"1013\" data-end=\"1063\">MHC-II\uff1a<br data-start=\"1020\" data-end=\"1023\" \/><br \/>\n\u3000- \u30b3\u30f3\u30c8\u30ed\u30fc\u30ebDC<br data-start=\"1034\" data-end=\"1037\" \/><br \/>\n\u3000- DL312 DC<br data-start=\"1048\" data-end=\"1051\" \/><br \/>\n\u3000- Ad-p53 DC<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1065\" data-end=\"1168\">\u4ebap53\u30bf\u30f3\u30d1\u30af\u8cea\u7531\u6765\u306e\u5168\u30da\u30d7\u30c1\u30c9\u914d\u5217\u306e\u3046\u3061\u3001<strong data-start=\"1088\" data-end=\"1104\">\u30de\u30a6\u30b9p53\u3068\u5171\u901a\u306e\u914d\u5217<\/strong>\u3092\u542b\u3080\u3082\u306e\u3084\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7531\u6765\u306eMHC-I\/II\u306b\u542b\u307e\u308c\u308b\u3082\u306e\u306f\u89e3\u6790\u5bfe\u8c61\u304b\u3089\u9664\u5916\u3057\u307e\u3057\u305f\uff08\u5185\u56e0\u6027p53\u7531\u6765\u3068\u533a\u5225\u3067\u304d\u306a\u3044\u305f\u3081\uff09\u3002<\/p>\n<p data-start=\"1170\" data-end=\"1175\">\u305d\u306e\u7d50\u679c\uff1a<\/p>\n<ul data-start=\"1177\" data-end=\"1286\">\n<li data-start=\"1177\" data-end=\"1286\">\n<p data-start=\"1179\" data-end=\"1286\"><strong data-start=\"1179\" data-end=\"1263\">Ad-p53 DCs\u304a\u3088\u3073OBP-702\u611f\u67d3CT26\u7d30\u80de\u306f\u3001\u3044\u305a\u308c\u3082MHC\u306b\u7d50\u5408\u3057\u305fp53\u306e63\u201379\u756a\u30a2\u30df\u30ce\u9178\u914d\u5217\uff08APRMPEAAPPVAPAPAA\uff09\u3092\u63d0\u793a<\/strong>\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\uff08\u56f35B\u3001\u88dc\u8db3\u88681\uff09<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1288\" data-end=\"1362\">&#x27a1;&#xfe0f; \u3053\u308c\u306f\u3001<strong data-start=\"1295\" data-end=\"1354\">\u4ebap53\u7531\u6765\u30da\u30d7\u30c1\u30c9\uff08p5363\u201379\uff09\u304c\u3001DC\u3068\u816b\u760d\u7d30\u80de\u306e\u4e21\u65b9\u3067\u63d0\u793a\u3055\u308c\u3001\u514d\u75ab\u5fdc\u7b54\u306e\u5171\u901a\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u306a\u308a\u5f97\u308b<\/strong>\u3053\u3068\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n<h2 data-start=\"39\" data-end=\"77\">ELISPOT\u30a2\u30c3\u30bb\u30a4\u306b\u3088\u308bp53\u30da\u30d7\u30c1\u30c9\u306b\u5bfe\u3059\u308bCTL\u5fdc\u7b54\u306e\u8a55\u4fa1<\/h2>\n<p data-start=\"78\" data-end=\"143\">\uff08Evaluation of CTL responses to p53 peptides using ELISPOT assay\uff09<\/p>\n<p data-start=\"145\" data-end=\"256\">\u6b21\u306b\u3001p53\u30da\u30d7\u30c1\u30c9\u304c<strong data-start=\"156\" data-end=\"187\">\u816b\u760d\u6297\u539f\uff08tumor antigen\uff09\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u304b<\/strong>\u3069\u3046\u304b\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u306b\u3001\u5408\u6210\u30da\u30d7\u30c1\u30c9\u3092\u7528\u3044\u305fELISPOT\u30a2\u30c3\u30bb\u30a4\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002\u4f7f\u7528\u3057\u305f\u30da\u30d7\u30c1\u30c9\u306f\u4ee5\u4e0b\u306e3\u7a2e\u985e\u306e\u30d2\u30c8p53\u7531\u6765\u914d\u5217\u3067\u3059\uff1a<\/p>\n<ul data-start=\"258\" data-end=\"322\">\n<li data-start=\"258\" data-end=\"279\">\n<p data-start=\"260\" data-end=\"279\">p53\u2076\u00b3\u207b\u2077\u2070\uff1aAPRMPEAA<\/p>\n<\/li>\n<li data-start=\"280\" data-end=\"302\">\n<p data-start=\"282\" data-end=\"302\">p53\u2076\u2075\u207b\u2077\u00b3\uff1aRMPEAAPPV<\/p>\n<\/li>\n<li data-start=\"303\" data-end=\"322\">\n<p data-start=\"305\" data-end=\"322\">p53\u2077\u00b2\u207b\u2077\u2079\uff1aPVAPAPAA<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"324\" data-end=\"415\">Ad-p53 DC\u514d\u75ab\u30de\u30a6\u30b9\u3068\u5bfe\u7167\u30de\u30a6\u30b9\u304b\u3089\u813e\u7d30\u80de\u3092\u63a1\u53d6\u3057\u3001IL-2\u3067\u523a\u6fc0\u5f8c\u3001\u4e0a\u8a18\u30da\u30d7\u30c1\u30c9\u6df7\u5408\u7269\u306872\u6642\u9593\u5171\u57f9\u990a\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u3001IFN-\u03b3\u7523\u751f\u7d30\u80de\u6570\u3092ELISPOT\u3067\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002<\/p>\n<p data-start=\"417\" data-end=\"420\">\u7d50\u679c\uff1a<\/p>\n<ul data-start=\"422\" data-end=\"501\">\n<li data-start=\"422\" data-end=\"501\">\n<p data-start=\"424\" data-end=\"501\">Ad-p53 DC\u514d\u75ab\u30de\u30a6\u30b9\u304b\u3089\u306e\u813e\u7d30\u80de\u306f\u3001p53\u30da\u30d7\u30c1\u30c9\u6df7\u5408\u7269\u306b\u53cd\u5fdc\u3057\u3066\u660e\u78ba\u306a**CD8\u207aT\u7d30\u80de\u5fdc\u7b54\uff08IFN-\u03b3\u30b9\u30dd\u30c3\u30c8\u5f62\u6210\uff09**\u3092\u793a\u3057\u307e\u3057\u305f\uff08\u56f35C\uff09<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"503\" data-end=\"583\">&#x27a1;&#xfe0f; \u3053\u308c\u306f\u3001<strong data-start=\"510\" data-end=\"574\">OBP-702\u611f\u67d3\u816b\u760d\u7d30\u80de\u304c\u63d0\u793a\u3059\u308bp53\u30da\u30d7\u30c1\u30c9\u306b\u5bfe\u3057\u3066\u3001Ad-p53 DC\u30ef\u30af\u30c1\u30f3\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u305fCTL\u304c\u53cd\u5fdc\u3059\u308b<\/strong>\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002<\/p>\n<hr data-start=\"585\" data-end=\"588\" \/>\n<h2 data-start=\"590\" data-end=\"639\">Ad-p53 DC\u30ef\u30af\u30c1\u30f3\u306b\u3088\u308bp53\u30da\u30d7\u30c1\u30c9\u7279\u7570\u7684CTL\u306e\u8a98\u5c0e\u8a55\u4fa1\uff08\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\uff09<\/h2>\n<p data-start=\"641\" data-end=\"705\">\u3055\u3089\u306b\u3001Ad-p53 DC\u30ef\u30af\u30c1\u30f3\u304c<strong data-start=\"659\" data-end=\"683\">p53\u30da\u30d7\u30c1\u30c9\u7279\u7570\u7684CTL\u3092\u8a98\u5c0e\u3067\u304d\u308b\u304b<\/strong>\u3092\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u306b\u3088\u308a\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002<\/p>\n<p data-start=\"707\" data-end=\"710\">\u65b9\u6cd5\uff1a<\/p>\n<ul data-start=\"712\" data-end=\"826\">\n<li data-start=\"712\" data-end=\"744\">\n<p data-start=\"714\" data-end=\"744\">Ad-p53 DC\u514d\u75ab\u30de\u30a6\u30b9\u3068\u5bfe\u7167\u30de\u30a6\u30b9\u304b\u3089\u813e\u7d30\u80de\u3092\u63a1\u53d6<\/p>\n<\/li>\n<li data-start=\"745\" data-end=\"768\">\n<p data-start=\"747\" data-end=\"768\">IL-2\u3067\u523a\u6fc0\u3057\u3001CD8\u207aT\u7d30\u80de\u3092\u8a98\u5c0e<\/p>\n<\/li>\n<li data-start=\"769\" data-end=\"792\">\n<p data-start=\"771\" data-end=\"792\">\u5408\u6210p53\u30da\u30d7\u30c1\u30c9\u6df7\u5408\u7269\u30686\u6642\u9593\u5171\u57f9\u990a<\/p>\n<\/li>\n<li data-start=\"793\" data-end=\"826\">\n<p data-start=\"795\" data-end=\"826\">IFN-\u03b3\u304a\u3088\u3073\u30b0\u30e9\u30f3\u30b6\u30a4\u30e0B\u306e\u767a\u73fe\u3092FACS\u3067\u8a55\u4fa1\uff08\u56f35D\uff09<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"828\" data-end=\"831\">\u7d50\u679c\uff1a<\/p>\n<ul data-start=\"833\" data-end=\"915\">\n<li data-start=\"833\" data-end=\"915\">\n<p data-start=\"835\" data-end=\"915\">Ad-p53 DC\u514d\u75ab\u30de\u30a6\u30b9\u7531\u6765\u306eCD8\u207aT\u7d30\u80de\u306f\u3001<strong data-start=\"861\" data-end=\"898\">IFN-\u03b3\u207a\u304a\u3088\u3073\u30b0\u30e9\u30f3\u30b6\u30a4\u30e0B\u207aCD8\u207aT\u7d30\u80de\u306e\u5272\u5408\u304c\u6709\u610f\u306b\u9ad8\u304f<\/strong>\u3001\u5bfe\u7167\u7fa4\u3088\u308a\u3082\u5f37\u3044\u53cd\u5fdc\u3092\u793a\u3057\u307e\u3057\u305f<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"917\" data-end=\"978\">&#x27a1;&#xfe0f; \u3053\u308c\u306b\u3088\u308a\u3001<strong data-start=\"926\" data-end=\"978\">Ad-p53 DC\u30ef\u30af\u30c1\u30f3\u304cp53\u30da\u30d7\u30c1\u30c9\u3092\u6a19\u7684\u3068\u3059\u308bCTL\u3092\u6709\u52b9\u306b\u8a98\u5c0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/strong><\/p>\n<h2 data-start=\"47\" data-end=\"107\">p53\u5909\u7570\u578bMC38\u816b\u760d\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308bAd-p53 DC\u304a\u3088\u3073OBP-702\u4f75\u7528\u7642\u6cd5\u306ein vivo\u6297\u816b\u760d\u52b9\u679c<\/h2>\n<p data-start=\"108\" data-end=\"210\">\uff08In vivo antitumor effect of Ad-p53 DC and OBP-702 combination therapy against p53-mutant MC38 tumors\uff09<\/p>\n<p data-start=\"212\" data-end=\"312\">\u6b21\u306b\u3001p53\u5909\u7570\u578b\u306e\u30de\u30a6\u30b9\u5927\u8178\u304c\u3093\u7d30\u80de\u682a\u3067\u3042\u308b<strong data-start=\"235\" data-end=\"243\">MC38<\/strong>\u3092\u7528\u3044\u3066\u3001Ad-p53 DCs\u304a\u3088\u3073OBP-702\u306e\u4f75\u7528\u7642\u6cd5\u306e\u6cbb\u7642\u52b9\u679c\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002MC38\u7d30\u80de\u306f\u5909\u7570\u578bp53\u3092\u904e\u5270\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u00b9\u2078\u3002<\/p>\n<p data-start=\"314\" data-end=\"385\">\u307e\u305a\u3001OBP-702\u309272\u6642\u9593\u611f\u67d3\u3055\u305b\u305fMC38\u7d30\u80de\u3067\u306f\u3001<strong data-start=\"343\" data-end=\"375\">XTT\u30a2\u30c3\u30bb\u30a4\u306b\u304a\u3044\u3066\u7d30\u80de\u751f\u5b58\u7387\u304c\u7528\u91cf\u4f9d\u5b58\u7684\u306b\u6709\u610f\u306b\u4f4e\u4e0b<\/strong>\u3057\u307e\u3057\u305f\uff08\u56f36A\uff09\u3002<\/p>\n<p data-start=\"387\" data-end=\"481\">\u3055\u3089\u306b\u3001\u611f\u67d3\u5f8c24\u6642\u9593\u3067\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0RT-PCR\u304a\u3088\u3073\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u89e3\u6790\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001<strong data-start=\"433\" data-end=\"464\">\u30d2\u30c8p53 mRNA\u304a\u3088\u3073\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u304c\u6709\u610f\u306b\u5897\u52a0<\/strong>\u3057\u307e\u3057\u305f\uff08\u56f36B\u30fbC\u3001\u88dc\u8db3\u56f35\uff09\u3002<\/p>\n<p data-start=\"483\" data-end=\"547\">&#x27a1;&#xfe0f; \u3053\u306e\u3053\u3068\u304b\u3089\u3001MC38\u7d30\u80de\u3082<strong data-start=\"500\" data-end=\"539\">OBP-702\u306e\u30a6\u30a4\u30eb\u30b9\u6027\u7d30\u80de\u969c\u5bb3\u52b9\u679c\u304a\u3088\u3073p53\u6d3b\u6027\u5316\u306b\u611f\u53d7\u6027\u304c\u3042\u308b<\/strong>\u3068\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<hr data-start=\"549\" data-end=\"552\" \/>\n<h3 data-start=\"554\" data-end=\"576\">Ad-p53 DC\u5358\u72ec\u7642\u6cd5\u3067\u306f\u4e0d\u5341\u5206<\/h3>\n<p data-start=\"578\" data-end=\"623\">p53\u5909\u7570\u578bMC38\u816b\u760d\u306b\u5bfe\u3057\u3066\u3001Ad-p53 DCs\u5358\u72ec\u7642\u6cd5\u3067\u306e\u52b9\u679c\u3082\u691c\u8a3c\u3055\u308c\u307e\u3057\u305f\u304c\uff1a<\/p>\n<ul data-start=\"625\" data-end=\"709\">\n<li data-start=\"625\" data-end=\"709\">\n<p data-start=\"627\" data-end=\"709\">**4\u56de\u306e\u5b9a\u671f\u7684\u76ae\u4e0b\u6ce8\u5c04\uff08\u221221\u65e5, \u221214\u65e5, \u22127\u65e5, +6\u65e5\uff09**\u3092\u884c\u3063\u305f\u306b\u3082\u95a2\u308f\u3089\u305a\u3001<strong data-start=\"674\" data-end=\"704\">\u5358\u72ec\u7642\u6cd5\u3067\u306f\u816b\u760d\u5897\u6b96\u306e\u6291\u5236\u52b9\u679c\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f<\/strong>\uff08\u56f36D\uff09<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"711\" data-end=\"768\">&#x27a1;&#xfe0f; \u3053\u308c\u306f\u3001p53\u5909\u7570\u578b\u816b\u760d\u306b\u5bfe\u3057\u3066\u306f\u3001Ad-p53 DC\u5358\u4f53\u3067\u306f<strong data-start=\"745\" data-end=\"755\">\u52b9\u679c\u304c\u4e0d\u5341\u5206<\/strong>\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<hr data-start=\"770\" data-end=\"773\" \/>\n<h3 data-start=\"775\" data-end=\"798\">OBP-702\u3068\u306e\u4f75\u7528\u3067\u6cbb\u7642\u52b9\u679c\u304c\u5fa9\u6d3b<\/h3>\n<p data-start=\"800\" data-end=\"842\">\u6b21\u306b\u3001OBP-702\u3068\u306e<strong data-start=\"812\" data-end=\"820\">\u4f75\u7528\u7642\u6cd5<\/strong>\u3092\u540c\u69d8\u306eMC38\u816b\u760d\u30e2\u30c7\u30eb\u3067\u691c\u8a3c\u3057\u305f\u3068\u3053\u308d\uff1a<\/p>\n<ul data-start=\"844\" data-end=\"979\">\n<li data-start=\"844\" data-end=\"917\">\n<p data-start=\"846\" data-end=\"917\"><strong data-start=\"846\" data-end=\"872\">Ad-p53 DCs\u3068OBP-702\u306e\u4f75\u7528\u7fa4<\/strong>\u3067\u306f\u3001\u5bfe\u7167\u7fa4\u304a\u3088\u3073\u5358\u5264\u6cbb\u7642\u7fa4\u3068\u6bd4\u3079\u3066<strong data-start=\"890\" data-end=\"905\">\u816b\u760d\u306e\u5897\u6b96\u304c\u6709\u610f\u306b\u6291\u5236<\/strong>\u3055\u308c\u307e\u3057\u305f\uff08\u56f36F\u30fbG\uff09<\/p>\n<\/li>\n<li data-start=\"919\" data-end=\"979\">\n<p data-start=\"921\" data-end=\"979\">\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u89e3\u6790\u3067\u306f\u3001<strong data-start=\"932\" data-end=\"966\">CD8\u207aT\u7d30\u80de\u304a\u3088\u3073CD11c\u207aDC\u306e\u816b\u760d\u5185\u6d78\u6f64\u304c\u6709\u610f\u306b\u5897\u52a0<\/strong>\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u56f36H\u30fbI\uff09<\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"981\" data-end=\"984\" \/>\n<h3 data-start=\"986\" data-end=\"1015\">OBP-702\u611f\u67d3MC38\u7d30\u80de\u306ep53\u30da\u30d7\u30c1\u30c9\u63d0\u793a<\/h3>\n<p data-start=\"1017\" data-end=\"1121\">\u514d\u75ab\u30da\u30d7\u30c1\u30c9\u30aa\u30df\u30af\u30b9\u89e3\u6790\u306b\u3088\u308a\u3001OBP-702\u3067\u611f\u67d3\u3057\u305fMC38\u7d30\u80de\u304b\u3089\u306f\u3001<strong data-start=\"1055\" data-end=\"1106\">\u4ebap53\u7531\u6765\u306e63\u201375\u756a\u30da\u30d7\u30c1\u30c9\uff08APRMPEAAPPVAP\uff09\u304cMHC-I\u5206\u5b50\u306b\u7d50\u5408\u3057\u3066\u63d0\u793a<\/strong>\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f\u3002<\/p>\n<p data-start=\"1123\" data-end=\"1197\">\u3053\u306e\u914d\u5217\u306f\u3001\u5148\u306bCT26\u7d30\u80de\u3067\u691c\u51fa\u3055\u308c\u305f\u30da\u30d7\u30c1\u30c9\u3068\u540c\u4e00\u3067\u3042\u308a\u3001<strong data-start=\"1154\" data-end=\"1182\">\u5909\u7570\u578bp53\u816b\u760d\u3067\u3082\u5171\u901a\u306e\u30a8\u30d4\u30c8\u30fc\u30d7\u304c\u63d0\u793a\u3055\u308c\u308b<\/strong>\u3053\u3068\u3092\u793a\u5506\u3057\u307e\u3059\uff08\u88dc\u8db3\u88681\uff09\u3002<\/p>\n<hr data-start=\"1199\" data-end=\"1202\" \/>\n<h3 data-start=\"1204\" data-end=\"1229\">\u5168\u8eab\u6027\u514d\u75ab\u5fdc\u7b54\u306e\u8a98\u5c0e\u8a55\u4fa1\uff08LDH\u30a2\u30c3\u30bb\u30a4\uff09<\/h3>\n<p data-start=\"1231\" data-end=\"1295\">\u4f75\u7528\u7642\u6cd5\u304c<strong data-start=\"1236\" data-end=\"1265\">MC38\u306b\u5bfe\u3059\u308b\u5168\u8eab\u7684\u306aCTL\u53cd\u5fdc\u3092\u8a98\u5c0e\u3057\u3066\u3044\u308b\u304b<\/strong>\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u3001\u4ee5\u4e0b\u306e\u624b\u9806\u3067LDH\u30a2\u30c3\u30bb\u30a4\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\uff1a<\/p>\n<ol data-start=\"1297\" data-end=\"1430\">\n<li data-start=\"1297\" data-end=\"1340\">\n<p data-start=\"1300\" data-end=\"1340\">Ad-p53 DC\uff0bOBP-702\u6cbb\u7642\u30de\u30a6\u30b9\u304a\u3088\u3073\u5bfe\u7167\u30de\u30a6\u30b9\u304b\u3089\u813e\u7d30\u80de\u3092\u63a1\u53d6<\/p>\n<\/li>\n<li data-start=\"1341\" data-end=\"1368\">\n<p data-start=\"1344\" data-end=\"1368\">IL-2\u30677\u65e5\u9593\u523a\u6fc0\u3057\u3001CD8\u207aT\u7d30\u80de\u3092\u8a98\u5c0e<\/p>\n<\/li>\n<li data-start=\"1369\" data-end=\"1395\">\n<p data-start=\"1372\" data-end=\"1395\">\u653e\u5c04\u7dda\u7167\u5c04\u3057\u305fMC38\u7d30\u80de\u306824\u6642\u9593\u5171\u57f9\u990a<\/p>\n<\/li>\n<li data-start=\"1396\" data-end=\"1430\">\n<p data-start=\"1399\" data-end=\"1430\">\u816b\u760d\u7d30\u80de\u304b\u3089\u653e\u51fa\u3055\u308c\u305f**LDH\u91cf\uff08\u7d30\u80de\u969c\u5bb3\u306e\u6307\u6a19\uff09**\u3092\u6e2c\u5b9a<\/p>\n<\/li>\n<\/ol>\n<p data-start=\"1432\" data-end=\"1435\">\u7d50\u679c\uff1a<\/p>\n<ul data-start=\"1437\" data-end=\"1516\">\n<li data-start=\"1437\" data-end=\"1516\">\n<p data-start=\"1439\" data-end=\"1516\">\u4f75\u7528\u7642\u6cd5\u30de\u30a6\u30b9\u7531\u6765CD8\u207aT\u7d30\u80de\u306f\u3001MC38\u7d30\u80de\u306b\u5bfe\u3057\u3066<strong data-start=\"1467\" data-end=\"1483\">\u6709\u610f\u306b\u591a\u304f\u306eLDH\u3092\u653e\u51fa<\/strong>\u3055\u305b\u3001\u5bfe\u7167\u7fa4\u306b\u6bd4\u3079\u3066<strong data-start=\"1493\" data-end=\"1505\">\u5f37\u3044\u7d30\u80de\u50b7\u5bb3\u6d3b\u6027<\/strong>\u3092\u793a\u3057\u307e\u3057\u305f\uff08\u56f36J\uff09<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1518\" data-end=\"1594\">&#x27a1;&#xfe0f; OBP-702\u3068\u306e\u4f75\u7528\u7642\u6cd5\u306f\u3001<strong data-start=\"1536\" data-end=\"1583\">p53\u5909\u7570\u578bMC38\u816b\u760d\u306b\u304a\u3044\u3066\u3082\u6709\u52b9\u3067\u3042\u308a\u3001CTL\u3092\u4ecb\u3057\u305f\u6297\u816b\u760d\u514d\u75ab\u5fdc\u7b54\u3092\u6d3b\u6027\u5316\u3059\u308b<\/strong>\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p data-start=\"1518\" data-end=\"1594\">\u00a0<\/p>\n<h2 data-start=\"63\" data-end=\"80\">\u8003\u5bdf\uff08Discussion\uff09<\/h2>\n<p data-start=\"82\" data-end=\"280\">\u6a39\u72b6\u7d30\u80de\uff08DC\uff09\u3092\u7528\u3044\u305f\u30ef\u30af\u30c1\u30f3\u7642\u6cd5\u306f\u3001<strong data-start=\"102\" data-end=\"140\">\u816b\u760d\u7279\u7570\u7684\u306a\u7d30\u80de\u50b7\u5bb3\u6027T\u7d30\u80de\uff08CTL\uff09\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u6709\u671b\u306a\u514d\u75ab\u6cbb\u7642\u6cd5<\/strong>\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u00b9\u3002<br data-start=\"155\" data-end=\"158\" \/><br \/>\n\u3057\u304b\u3057\u3001\u3044\u308f\u3086\u308b\u300c\u30b3\u30fc\u30eb\u30c9\u30fb\u30c1\u30e5\u30fc\u30e2\u30a2\uff08\u514d\u75ab\u5b66\u7684\u306b\u4e0d\u6d3b\u767a\u306a\u816b\u760d\uff09\u300d\u3067\u306f\u3001\u816b\u760d\u306e\u514d\u75ab\u539f\u6027\u304c\u5f31\u304f\u3001CTL\u306e\u816b\u760d\u6d78\u6f64\u304c\u4e4f\u3057\u3044\u4e0a\u306b\u514d\u75ab\u6291\u5236\u7684\u306a\u816b\u760d\u5fae\u5c0f\u74b0\u5883\uff08TME\uff09\u304c\u5b58\u5728\u3059\u308b\u305f\u3081\u3001DC\u30ef\u30af\u30c1\u30f3\u7642\u6cd5\u306b\u5bfe\u3057\u3066<strong data-start=\"256\" data-end=\"270\">\u8010\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u591a\u3044<\/strong>\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u00b2\u2076\u3002<\/p>\n<p data-start=\"282\" data-end=\"358\">\u3057\u305f\u304c\u3063\u3066\u3001<strong data-start=\"288\" data-end=\"324\">\u816b\u760d\u306e\u514d\u75ab\u539f\u6027\u304a\u3088\u3073\u6297\u816b\u760d\u514d\u75ab\u5fdc\u7b54\u3092\u9ad8\u3081\u308b\u65b0\u305f\u306a\u514d\u75ab\u7642\u6cd5\u3068\u306e\u4f75\u7528<\/strong>\u304c\u3001DC\u30ef\u30af\u30c1\u30f3\u7642\u6cd5\u306e\u52b9\u679c\u3092\u6700\u5927\u9650\u306b\u5f15\u304d\u51fa\u3059\u4e0a\u3067\u91cd\u8981\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<hr data-start=\"360\" data-end=\"363\" \/>\n<h3 data-start=\"365\" data-end=\"377\">\u672c\u7814\u7a76\u306e\u4e3b\u306a\u77e5\u898b<\/h3>\n<p data-start=\"379\" data-end=\"401\">\u672c\u7814\u7a76\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\uff1a<\/p>\n<ul data-start=\"403\" data-end=\"732\">\n<li data-start=\"403\" data-end=\"478\">\n<p data-start=\"405\" data-end=\"478\">Ad-p53 DCs\u3068OBP-702\u306e<strong data-start=\"424\" data-end=\"474\">\u4f75\u7528\u7642\u6cd5\u306f\u3001p53\u91ce\u751f\u578b\u30fb\u5909\u7570\u578b\u306e\u30de\u30a6\u30b9\u5927\u8178\u304c\u3093\u816b\u760d\u30e2\u30c7\u30eb\u306e\u4e21\u65b9\u306b\u304a\u3044\u3066\u816b\u760d\u5897\u6b96\u3092\u8457\u3057\u304f\u6291\u5236<\/strong>\u3057\u305f<\/p>\n<\/li>\n<li data-start=\"479\" data-end=\"529\">\n<p data-start=\"481\" data-end=\"529\">\u3053\u306e\u6291\u5236\u52b9\u679c\u306f\u3001<strong data-start=\"489\" data-end=\"519\">\u816b\u760d\u6d78\u6f64CD8\u207aCTL\u304a\u3088\u3073CD11c\u207aDC\u306e\u6d3b\u6027\u5316<\/strong>\u3092\u4f34\u3063\u3066\u3044\u307e\u3057\u305f<\/p>\n<\/li>\n<li data-start=\"530\" data-end=\"586\">\n<p data-start=\"532\" data-end=\"586\">**OBP-702\u672a\u6cbb\u7642\u306e\u816b\u760d\u306b\u3082\u6297\u816b\u760d\u52b9\u679c\uff08\u30a2\u30d6\u30b9\u30b3\u30d1\u30eb\u52b9\u679c\uff09**\u3092\u793a\u3057\u3001\u5168\u8eab\u6027\u514d\u75ab\u5fdc\u7b54\u3092\u8a98\u5c0e\u3057\u307e\u3057\u305f<\/p>\n<\/li>\n<li data-start=\"587\" data-end=\"689\">\n<p data-start=\"589\" data-end=\"689\"><strong data-start=\"589\" data-end=\"674\">\u514d\u75ab\u30da\u30d7\u30c1\u30c9\u30aa\u30df\u30af\u30b9\u89e3\u6790\u306b\u3088\u308a\u3001OBP-702\u611f\u67d3\u816b\u760d\u7d30\u80de\u304a\u3088\u3073Ad-p53 DCs\u306e\u4e21\u65b9\u304c\u3001p5363\u201379\u30da\u30d7\u30c1\u30c9\uff08APRMPEAAPPVAPAPAA\uff09\u3092\u63d0\u793a<\/strong>\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3057\u305f<\/p>\n<\/li>\n<li data-start=\"690\" data-end=\"732\">\n<p data-start=\"692\" data-end=\"732\">\u3053\u306e\u30da\u30d7\u30c1\u30c9\u306b\u7279\u7570\u7684\u306aCTL\u304c\u3001OBP-702\u611f\u67d3\u816b\u760d\u7d30\u80de\u3092\u9078\u629e\u7684\u306b\u9664\u53bb\u3057\u307e\u3057\u305f<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"734\" data-end=\"850\">&#x27a1;&#xfe0f; \u4ee5\u4e0a\u3088\u308a\u3001<strong data-start=\"742\" data-end=\"840\">OBP-702\u3092\u7528\u3044\u305fp53\u5c0e\u5165\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\u3068Ad-p53 DC\u30ef\u30af\u30c1\u30f3\u7642\u6cd5\u306e\u4f75\u7528\u306f\u3001p53\u6297\u539f\u306e\u63d0\u793a\u3068\u305d\u308c\u306b\u5fdc\u7b54\u3059\u308bCTL\u306e\u816b\u760d\u52d5\u54e1\u3092\u6d3b\u6027\u5316\u3057\u3001\u5f37\u529b\u306a\u6297\u816b\u760d\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u65b0\u305f\u306a\u6226\u7565\u3067\u3042\u308b<\/strong>\u3068\u7d50\u8ad6\u3065\u3051\u3089\u308c\u307e\u3059\u3002<\/p>\n<hr data-start=\"852\" data-end=\"855\" \/>\n<h3 data-start=\"857\" data-end=\"880\">\u65e2\u5b58\u7642\u6cd5\u3068\u306e\u6bd4\u8f03\u3068OBP-702\u306e\u5229\u70b9<\/h3>\n<p data-start=\"882\" data-end=\"952\">\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u3082\u3001Ad-p53 DC\u30ef\u30af\u30c1\u30f3\u306f<strong data-start=\"906\" data-end=\"937\">p53\u767a\u73fe\u816b\u760d\u3092\u6a19\u7684\u3068\u3059\u308bCTL\u3092\u8a98\u5c0e\u3067\u304d\u308b\u6709\u671b\u306a\u6226\u7565<\/strong>\u3067\u3042\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u2075\u3002<\/p>\n<p data-start=\"954\" data-end=\"1116\">\u3057\u304b\u3057\u3001p53\u91ce\u751f\u578b\u816b\u760d\u306b\u304a\u3044\u3066\u306fp53\u306e\u767a\u73fe\u91cf\u304c\u5c11\u306a\u3044\u305f\u3081\u3001CTL\u306e\u52b9\u679c\u304c\u9650\u5b9a\u7684\u306b\u306a\u308b\u306e\u304c\u8ab2\u984c\u3067\u3057\u305f\u3002<br data-start=\"1006\" data-end=\"1009\" \/><br 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data-end=\"1190\">\n<p data-start=\"1171\" data-end=\"1190\">\u5316\u5b66\u7642\u6cd5\uff08p53\u3092\u9593\u63a5\u7684\u306b\u6d3b\u6027\u5316\uff09\u00b2\u2079<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1192\" data-end=\"1279\">\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306f<strong data-start=\"1205\" data-end=\"1237\">\u6b63\u5e38\u7d30\u80de\u306ep53\u3082\u6d3b\u6027\u5316\u3057\u3066\u3057\u307e\u3044\u3001\u526f\u4f5c\u7528\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b<\/strong>\u305f\u3081\u3001<strong data-start=\"1240\" data-end=\"1276\">\u816b\u760d\u7279\u7570\u7684\u306bp53\u3092\u767a\u73fe\u3055\u305b\u308bOBP-702\u306f\u5b89\u5168\u6027\u306e\u9762\u3067\u3082\u6709\u5229<\/strong>\u3067\u3059\u3002<\/p>\n<hr data-start=\"1281\" data-end=\"1284\" \/>\n<h3 data-start=\"1286\" data-end=\"1306\">\u5171\u901a\u30a8\u30d4\u30c8\u30fc\u30d7\u306e\u63d0\u793a\u3068\u5c06\u6765\u7684\u5c55\u671b<\/h3>\n<p data-start=\"1308\" data-end=\"1480\">\u4eca\u56de\u540c\u5b9a\u3055\u308c\u305f<strong data-start=\"1315\" data-end=\"1457\">p5363\u201375\uff08APRMPEAAPPVAP\uff09\u306a\u3069\u306e\u30da\u30d7\u30c1\u30c9\u306f\u3001MHC-I\u304a\u3088\u3073MHC-II\u3092\u901a\u3058\u3066DC\u304a\u3088\u3073\u816b\u760d\u7d30\u80de\u306b\u5171\u901a\u3057\u3066\u63d0\u793a\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<br data-start=\"1402\" data-end=\"1405\" \/><br \/>\n\u3053\u306e\u3046\u3061p5365\u201373\uff08RMPEAAPPV\uff09\u306f\u3001HLA-A2\u62d8\u675f\u6027\u30a8\u30d4\u30c8\u30fc\u30d7\u3068\u3057\u3066\u3082\u5831\u544a\u304c\u3042\u308a<\/strong>\u3001\u30d2\u30c8\u3078\u306e\u5fdc\u7528\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u00b3\u2070\u3002<\/p>\n<p data-start=\"1482\" data-end=\"1554\">&#x27a1;&#xfe0f; \u3088\u3063\u3066\u3001<strong data-start=\"1489\" data-end=\"1551\">\u4eca\u5f8c\u306e\u7814\u7a76\u3067\u306f\u3001Ad-p53 DC\uff0bOBP-702\u4f75\u7528\u7642\u6cd5\u304c\u30d2\u30c8\u5927\u8178\u304c\u3093\u306a\u3069\u3078\u306e\u5fdc\u7528\u306b\u6709\u52b9\u304b\u3069\u3046\u304b\u3001\u3055\u3089\u306b\u691c\u8a3c\u304c\u5fc5\u8981<\/strong>\u3067\u3059\u3002<\/p>\n<hr data-start=\"1556\" data-end=\"1559\" \/>\n<h3 data-start=\"1561\" data-end=\"1578\">\u30a2\u30d6\u30b9\u30b3\u30d1\u30eb\u52b9\u679c\u3068\u514d\u75ab\u8a18\u61b6<\/h3>\n<p data-start=\"1580\" data-end=\"1669\">\u672c\u7814\u7a76\u3067\u306f\u3001<strong data-start=\"1586\" data-end=\"1619\">\u4f75\u7528\u7642\u6cd5\u304c\u672a\u6cbb\u7642\u816b\u760d\u306b\u3082\u52b9\u679c\u3092\u53ca\u307c\u3059\u30a2\u30d6\u30b9\u30b3\u30d1\u30eb\u52b9\u679c\u3092\u793a\u3057<\/strong>\u3001\u3055\u3089\u306b\u6cbb\u7652\u3057\u305f\u30de\u30a6\u30b9\u3067\u306f\u518d\u63a5\u7a2e\u3057\u3066\u3082\u540c\u3058\u816b\u760d\u304c\u5f62\u6210\u3055\u308c\u306a\u3044\u3068\u3044\u3046<strong data-start=\"1652\" 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data-end=\"1835\">\u6295\u4e0e\u7d4c\u8def\u306b\u95a2\u3059\u308b\u8003\u5bdf<\/h3>\n<p data-start=\"1837\" data-end=\"1987\">\u672c\u7814\u7a76\u3067\u306f\u3001Ad-p53 DC\u306f<strong data-start=\"1853\" data-end=\"1861\">\u76ae\u4e0b\u6295\u4e0e<\/strong>\u306b\u3088\u308aT\u7d30\u80de\u5fdc\u7b54\u3092\u8a98\u5c0e\u3057\u307e\u3057\u305f\u304c\u3001<strong data-start=\"1878\" data-end=\"1887\">\u816b\u760d\u5185\u6295\u4e0e<\/strong>\u3082\u6709\u52b9\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u00b3\u2075,\u00b3\u2076\u3002<br data-start=\"1907\" data-end=\"1910\" \/><br \/>\n\u4eca\u5f8c\u306f\u3001<strong data-start=\"1914\" data-end=\"1979\">OBP-702\u3068Ad-p53 DC\u306e\u4e21\u8005\u3092\u816b\u760d\u5185\u306b\u4f75\u7528\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u5f37\u529b\u306a\u816b\u760d\u7279\u7570\u7684CTL\u5fdc\u7b54\u304c\u5f97\u3089\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b<\/strong>\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<hr data-start=\"1989\" data-end=\"1992\" \/>\n<h3 data-start=\"1994\" data-end=\"2000\">\u7d50\u8ad6<\/h3>\n<p data-start=\"2002\" data-end=\"2146\">\u672c\u7814\u7a76\u306f\u3001p53\u3092\u5c0e\u5165\u3057\u305f\u816b\u760d\u6eb6\u89e3\u6027\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u300cOBP-702\u300d\u304c\u3001Ad-p53 DC\u30ef\u30af\u30c1\u30f3\u306e\u6297\u816b\u760d\u52b9\u679c\u3092\u9ad8\u3081\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002<br data-start=\"2070\" data-end=\"2073\" \/><br \/>\n\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001<strong data-start=\"2082\" data-end=\"2141\">MHC\u5206\u5b50\u306b\u7d50\u5408\u3057\u305fp53\u30da\u30d7\u30c1\u30c9\u306e\u63d0\u793a\u3092\u4ecb\u3057\u3066\u3001p53\u7279\u7570\u7684CTL\u3092\u816b\u760d\u3078\u8a98\u5c0e\u3057\u3001\u5f37\u529b\u306a\u514d\u75ab\u5fdc\u7b54\u3092\u5f15\u304d\u8d77\u3053\u3059<\/strong>\u3082\u306e\u3067\u3059\u3002<\/p>\n<p data-start=\"2148\" data-end=\"2221\">&#x27a1;&#xfe0f; \u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001Ad-p53 DC\uff0bOBP-702\u306e\u4f75\u7528\u7642\u6cd5\u304c\u3001<strong data-start=\"2183\" data-end=\"2208\">\u65b0\u305f\u306a\u6297\u816b\u760d\u514d\u75ab\u7642\u6cd5\u306e\u57fa\u76e4\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u308b<\/strong>\u3053\u3068\u3092\u5f37\u304f\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p data-start=\"2148\" data-end=\"2221\">\u00a0<\/p>\n<p data-start=\"2148\" data-end=\"2221\">\u00a0<\/p>\n<h2 data-start=\"105\" data-end=\"136\">\u6750\u6599\u3068\u65b9\u6cd5\uff08Materials and Methods\uff09<\/h2>\n<h3 data-start=\"138\" data-end=\"157\">\u7d30\u80de\u682a\uff08Cell lines\uff09<\/h3>\n<p data-start=\"159\" data-end=\"179\">\u4ee5\u4e0b\u306e\u30de\u30a6\u30b9\u7531\u6765\u304c\u3093\u7d30\u80de\u682a\u3092\u7528\u3044\u307e\u3057\u305f\uff1a<\/p>\n<ul data-start=\"181\" data-end=\"357\">\n<li data-start=\"181\" data-end=\"291\">\n<p data-start=\"183\" data-end=\"291\"><strong data-start=\"183\" data-end=\"197\">CT26\u5927\u8178\u304c\u3093\u7d30\u80de<\/strong>\u304a\u3088\u3073<strong data-start=\"200\" data-end=\"212\">4T1\u4e73\u304c\u3093\u7d30\u80de<\/strong>\uff08\u3044\u305a\u308c\u3082BALB\/c\u30de\u30a6\u30b9\u7531\u6765\uff09\uff1a<br data-start=\"230\" data-end=\"233\" \/><br \/>\n\u3000\u5165\u624b\u5148\uff1aAmerican Type Culture Collection\uff08ATCC, \u7c73\u56fd\u30d0\u30fc\u30b8\u30cb\u30a2\u5dde\u30de\u30ca\u30c3\u30b5\u30b9\uff09<\/p>\n<\/li>\n<li data-start=\"293\" data-end=\"357\">\n<p data-start=\"295\" data-end=\"357\"><strong data-start=\"295\" data-end=\"309\">MC38\u5927\u8178\u304c\u3093\u7d30\u80de<\/strong>\uff08C57BL\/6\u30de\u30a6\u30b9\u7531\u6765\uff09\uff1a<br data-start=\"324\" data-end=\"327\" \/><br \/>\n\u3000\u5165\u624b\u5148\uff1aKerafast\uff08\u7c73\u56fd\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u5dde\u30dc\u30b9\u30c8\u30f3\uff09<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"359\" data-end=\"410\">CT26\u7d30\u80de\u306f<strong data-start=\"366\" data-end=\"376\">p53\u91ce\u751f\u578b<\/strong>\u3001MC38\u7d30\u80de\u306f<strong data-start=\"384\" data-end=\"394\">p53\u5909\u7570\u578b<\/strong>\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u00b9\u2078\u3002<\/p>\n<ul data-start=\"412\" data-end=\"528\">\n<li data-start=\"412\" data-end=\"454\">\n<p data-start=\"414\" data-end=\"454\">CT26\u7d30\u80de\u306e\u57f9\u990a\u6761\u4ef6\uff1aRPMI-1640\u57f9\u5730\uff0b10%\u30a6\u30b7\u80ce\u5150\u8840\u6e05\uff08FBS\uff09<\/p>\n<\/li>\n<li data-start=\"455\" data-end=\"485\">\n<p data-start=\"457\" data-end=\"485\">MC38\u7d30\u80de\u306e\u57f9\u990a\u6761\u4ef6\uff1aDMEM\u57f9\u5730\uff0b10% FBS<\/p>\n<\/li>\n<li data-start=\"486\" data-end=\"528\">\n<p data-start=\"488\" data-end=\"528\">\u5171\u901a\u6761\u4ef6\uff1a100 U\/mL\u30da\u30cb\u30b7\u30ea\u30f3\u3001100 \u03bcg\/mL\u30b9\u30c8\u30ec\u30d7\u30c8\u30de\u30a4\u30b7\u30f3\u3092\u6dfb\u52a0<\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"530\" data-end=\"533\" \/>\n<h3 data-start=\"535\" data-end=\"578\">\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\uff08Recombinant adenoviruses\uff09<\/h3>\n<p data-start=\"580\" data-end=\"600\">\u4f7f\u7528\u3057\u305f\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\uff1a<\/p>\n<ul data-start=\"602\" data-end=\"904\">\n<li data-start=\"602\" data-end=\"698\">\n<p data-start=\"604\" data-end=\"698\"><strong data-start=\"604\" data-end=\"626\">OBP-301\uff08\u30b9\u30e9\u30bf\u30c7\u30ce\u30c1\u30e5\u30ec\u30d6\uff09<\/strong>\uff1a\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u7279\u7570\u7684\u306a\u8907\u88fd\u80fd\u3092\u6301\u3064\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u3002<br data-start=\"651\" data-end=\"654\" \/><br \/>\n\u3000hTERT\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306b\u3088\u308aE1A\u304a\u3088\u3073E1B\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3002\u4ee5\u524d\u306b\u69cb\u7bc9\u6e08\u307f\u2078\u2079\u3002<\/p>\n<\/li>\n<li data-start=\"700\" data-end=\"784\">\n<p data-start=\"702\" data-end=\"784\"><strong data-start=\"702\" data-end=\"713\">OBP-702<\/strong>\uff1aOBP-301\u306eE3\u9818\u57df\u306b<strong data-start=\"727\" data-end=\"757\">Egr-1\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u5236\u5fa1\u4e0b\u306e\u30d2\u30c8p53\u767a\u73fe\u30ab\u30bb\u30c3\u30c8<\/strong>\u3092\u633f\u5165\u3057\u3066\u4f5c\u88fd\u00b9\u00b3\u3002<br data-start=\"767\" data-end=\"770\" \/><br \/>\n\u3000\u816b\u760d\u7279\u7570\u7684\u306bp53\u3092\u767a\u73fe\u3002<\/p>\n<\/li>\n<li data-start=\"786\" data-end=\"844\">\n<p data-start=\"788\" data-end=\"844\"><strong data-start=\"788\" data-end=\"798\">Ad-p53<\/strong>\uff1a\u8907\u88fd\u4e0d\u80fd\u578b\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u3067\u3001\u30d2\u30c8\u91ce\u751f\u578bp53\u3092\u767a\u73fe\u3002DC\u3078\u306e\u907a\u4f1d\u5b50\u5c0e\u5165\u306b\u4f7f\u7528\uff08\u88dc\u8db3\u56f31A\uff09<\/p>\n<\/li>\n<li data-start=\"846\" data-end=\"904\">\n<p data-start=\"848\" data-end=\"904\"><strong data-start=\"848\" data-end=\"857\">DL312<\/strong>\uff1aE1A\u9818\u57df\u304c\u6b20\u640d\u3057\u305f\u8907\u88fd\u4e0d\u80fd\u578b\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9\u3067\u3001Ad-p53 DC\u306e\u5bfe\u7167\u306b\u4f7f\u7528\uff08\u88dc\u8db3\u56f31B\uff09<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"906\" data-end=\"977\">\u3044\u305a\u308c\u306e\u30a6\u30a4\u30eb\u30b9\u3082\u3001<strong data-start=\"916\" data-end=\"934\">\u5869\u5316\u30bb\u30b7\u30a6\u30e0\u5bc6\u5ea6\u52fe\u914d\u8d85\u9060\u5fc3\u6cd5<\/strong>\u3067\u7cbe\u88fd\u3057\u3001293\u7d30\u80de\u3067\u30d7\u30e9\u30fc\u30af\u30a2\u30c3\u30bb\u30a4\u306b\u3088\u308a\u529b\u4fa1\uff08PFU\uff09\u3092\u6e2c\u5b9a\u5f8c\u3001\u221280\u00b0C\u3067\u4fdd\u5b58\u3002<\/p>\n<hr data-start=\"979\" data-end=\"982\" \/>\n<h3 data-start=\"984\" data-end=\"1027\">Ad-p53 DC\u306e\u8abf\u88fd\uff08Preparation of Ad-p53 DCs\uff09<\/h3>\n<p data-start=\"1029\" data-end=\"1060\">\u30de\u30a6\u30b9\u9aa8\u9ac4\u7531\u6765\u7d30\u80de\uff08BMDC\uff09\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u3057\u3066\u8abf\u88fd\u3057\u307e\u3057\u305f\uff1a<\/p>\n<ol data-start=\"1062\" data-end=\"1357\">\n<li data-start=\"1062\" data-end=\"1110\">\n<p data-start=\"1065\" data-end=\"1110\"><strong data-start=\"1065\" data-end=\"1073\">\u30de\u30a6\u30b9\u7a2e<\/strong>\uff1aBALB\/c\u304a\u3088\u3073C57BL\/6J\uff08CLEA Japan\u793e\u3088\u308a\u8cfc\u5165\uff09<\/p>\n<\/li>\n<li data-start=\"1111\" data-end=\"1144\">\n<p data-start=\"1114\" data-end=\"1144\"><strong data-start=\"1114\" data-end=\"1120\">\u9ebb\u9154<\/strong>\uff1a2%\u30a4\u30bd\u30d5\u30eb\u30e9\u30f3\u5438\u5165\u5f8c\u3001\u9838\u690e\u8131\u81fc\u306b\u3066\u5b89\u697d\u6b7b<\/p>\n<\/li>\n<li data-start=\"1145\" data-end=\"1164\">\n<p data-start=\"1148\" data-end=\"1164\"><strong data-start=\"1148\" data-end=\"1158\">\u9aa8\u9ac4\u62bd\u51fa\u90e8\u4f4d<\/strong>\uff1a\u5927\u817f\u9aa8<\/p>\n<\/li>\n<li data-start=\"1165\" data-end=\"1243\">\n<p data-start=\"1168\" data-end=\"1243\"><strong data-start=\"1168\" data-end=\"1176\">\u5206\u5316\u8a98\u5c0e<\/strong>\uff1a<br data-start=\"1177\" data-end=\"1180\" \/><br \/>\n\u3000- GM-CSF\uff0840 ng\/mL, Sigma\uff09<br data-start=\"1206\" data-end=\"1209\" \/><br \/>\n\u3000- IL-4\uff0810 ng\/mL, Sigma\uff09<br data-start=\"1233\" data-end=\"1236\" \/><br \/>\n\u3000\u30675\u65e5\u9593\u57f9\u990a<\/p>\n<\/li>\n<li data-start=\"1245\" data-end=\"1357\">\n<p data-start=\"1248\" data-end=\"1357\"><strong data-start=\"1248\" data-end=\"1258\">\u30a6\u30a4\u30eb\u30b9\u611f\u67d3<\/strong>\uff1a<br data-start=\"1259\" data-end=\"1262\" \/><br \/>\n\u3000- Ad-p53\u307e\u305f\u306fDL312\uff08\u5404MOI = 100 PFU\/\u7d30\u80de\uff09\u30672\u65e5\u9593\u611f\u67d3<br data-start=\"1304\" data-end=\"1307\" \/><br \/>\n\u3000- \u5f97\u3089\u308c\u305fDC\u3092\u3001\u305d\u308c\u305e\u308c<strong data-start=\"1322\" data-end=\"1336\">Ad-p53 DCs<\/strong>\u307e\u305f\u306f<strong data-start=\"1339\" data-end=\"1352\">DL312 DCs<\/strong>\u3068\u3057\u3066\u4f7f\u7528<\/p>\n<\/li>\n<\/ol>\n<h3 data-start=\"53\" data-end=\"96\">\u5b9a\u91cf\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR\uff08Quantitative real-time PCR\uff09<\/h3>\n<p data-start=\"98\" data-end=\"113\">RNA\u62bd\u51fa\u304a\u3088\u3073cDNA\u5408\u6210\uff1a<\/p>\n<ul data-start=\"115\" data-end=\"242\">\n<li data-start=\"115\" data-end=\"149\">\n<p data-start=\"117\" data-end=\"149\">\u5bfe\u8c61\uff1a\u30b3\u30f3\u30c8\u30ed\u30fc\u30ebDC\u3001DL312 DC\u3001Ad-p53 DC<\/p>\n<\/li>\n<li data-start=\"150\" data-end=\"189\">\n<p data-start=\"152\" data-end=\"189\">\u62bd\u51fa\u30ad\u30c3\u30c8\uff1amiRNeasy Mini Kit\uff08Qiagen, \u7c73\u56fd\uff09<\/p>\n<\/li>\n<li data-start=\"190\" data-end=\"242\">\n<p data-start=\"192\" data-end=\"242\">cDNA\u5408\u6210\uff1aTaqMan\u30ea\u30d0\u30fc\u30b9\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30b7\u30e7\u30f3\u30ad\u30c3\u30c8\uff08Applied Biosystems\uff09<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"244\" data-end=\"256\">\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0PCR\u6e2c\u5b9a\uff1a<\/p>\n<ul data-start=\"258\" data-end=\"389\">\n<li data-start=\"258\" data-end=\"298\">\n<p data-start=\"260\" data-end=\"298\">\u88c5\u7f6e\uff1aStepOne-Plus&#x2122;\uff08Applied Biosystems\uff09<\/p>\n<\/li>\n<li data-start=\"299\" data-end=\"389\">\n<p data-start=\"301\" data-end=\"389\">\u30d7\u30e9\u30a4\u30de\u30fc\uff1a<br data-start=\"307\" data-end=\"310\" \/><br \/>\n\u3000- \u30d2\u30c8p53\uff1aTP53\uff08Hs01034253_m1\uff09<br data-start=\"338\" data-end=\"341\" \/><br \/>\n\u3000- \u5185\u90e8\u5bfe\u7167\uff1aGapdh\uff08Mm99999915_g1\uff09\u3001Actb\uff08Mm02619580_g1\uff09<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"391\" data-end=\"447\">\u767a\u73fe\u91cf\u306f**\u0394\u0394Ct\u6cd5\uff082^-\u0394\u0394Ct\uff09**\u306b\u3088\u308a\u7b97\u51fa\u3057\u3001GAPDH\u307e\u305f\u306fActb\u3067\u6b63\u898f\u5316\uff08\u56f31B\u3001\u88dc\u8db3\u56f32\uff09\u3002<\/p>\n<hr data-start=\"449\" data-end=\"452\" \/>\n<h3 data-start=\"454\" data-end=\"485\">\u514d\u75ab\u7d30\u80de\u67d3\u8272\uff08Immunocytochemistry\uff09<\/h3>\n<ul data-start=\"487\" data-end=\"697\">\n<li data-start=\"487\" data-end=\"521\">\n<p data-start=\"489\" data-end=\"521\">DC\u306f1\u00d710\u2076\u7d30\u80de\/\u30a6\u30a7\u30eb\u306e\u5bc6\u5ea6\u306712\u30a6\u30a7\u30eb\u30d7\u30ec\u30fc\u30c8\u306b\u64ad\u7a2e<\/p>\n<\/li>\n<li data-start=\"522\" data-end=\"542\">\n<p data-start=\"524\" data-end=\"542\">\u56fa\u5b9a\u6db2\uff1a4%\u30d1\u30e9\u30db\u30eb\u30e0\u30a2\u30eb\u30c7\u30d2\u30c9<\/p>\n<\/li>\n<li data-start=\"543\" data-end=\"557\">\n<p data-start=\"545\" data-end=\"557\">\u900f\u904e\u51e6\u7406\uff1a\u30e1\u30bf\u30ce\u30fc\u30eb<\/p>\n<\/li>\n<li data-start=\"558\" data-end=\"605\">\n<p data-start=\"560\" data-end=\"605\">\u4e00\u6b21\u6297\u4f53\uff1a\u30d2\u30c8p53\uff081:800\u3001Cell Signaling Technology\uff09<\/p>\n<\/li>\n<li data-start=\"606\" data-end=\"648\">\n<p data-start=\"608\" data-end=\"648\">\u4e8c\u6b21\u6297\u4f53\uff1aAlexa Fluor 647\uff081:500\u3001Invitrogen\uff09<\/p>\n<\/li>\n<li data-start=\"649\" data-end=\"661\">\n<p data-start=\"651\" data-end=\"661\">\u6838\u67d3\u8272\uff1aDAPI<\/p>\n<\/li>\n<li data-start=\"662\" data-end=\"697\">\n<p data-start=\"664\" data-end=\"697\">\u64ae\u50cf\uff1a\u5171\u7126\u70b9\u30ec\u30fc\u30b6\u30fc\u30b9\u30ad\u30e3\u30cb\u30f3\u30b0\u9855\u5fae\u93e1\uff08IX83\u3001Olympus\uff09<\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"699\" data-end=\"702\" \/>\n<h3 data-start=\"704\" data-end=\"746\">\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u89e3\u6790\uff08Flow cytometric analysis\uff09<\/h3>\n<p data-start=\"748\" data-end=\"753\">\u89e3\u6790\u5bfe\u8c61\uff1a<\/p>\n<ul data-start=\"755\" data-end=\"875\">\n<li data-start=\"755\" data-end=\"800\">\n<p data-start=\"757\" data-end=\"800\">DC\u6210\u719f\u30de\u30fc\u30ab\u30fc\uff1aCD11c, CD86, CD103, CCR7, MHC-II<\/p>\n<\/li>\n<li data-start=\"801\" data-end=\"839\">\n<p data-start=\"803\" data-end=\"839\">\u816b\u760d\u5185\u514d\u75ab\u7d30\u80de\uff1aCD45\u207a\u9020\u8840\u7d30\u80de\u3001CD8\u207aT\u7d30\u80de\u3001CD11c\u207aDC<\/p>\n<\/li>\n<li data-start=\"840\" data-end=\"875\">\n<p data-start=\"842\" data-end=\"875\">CD8\u207aT\u7d30\u80de\u306e\u6d3b\u6027\u5316\u30de\u30fc\u30ab\u30fc\uff1aCD137, CD69, PD-1<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"877\" data-end=\"882\">\u89e3\u6790\u65b9\u6cd5\uff1a<\/p>\n<ul data-start=\"884\" data-end=\"982\">\n<li data-start=\"884\" data-end=\"899\">\n<p data-start=\"886\" data-end=\"899\">\u86cd\u5149\u6a19\u8b58\u4e00\u6b21\u6297\u4f53\u3067\u67d3\u8272<\/p>\n<\/li>\n<li data-start=\"900\" data-end=\"921\">\n<p data-start=\"902\" data-end=\"921\">\u540c\u7a2e\u5bfe\u7167IgG\u306b\u3066\u9670\u6027\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb<\/p>\n<\/li>\n<li data-start=\"922\" data-end=\"956\">\n<p data-start=\"924\" data-end=\"956\">\u6e2c\u5b9a\u6a5f\u5668\uff1aBD FACSLyric \u307e\u305f\u306f FACSAria<\/p>\n<\/li>\n<li data-start=\"957\" data-end=\"982\">\n<p data-start=\"959\" data-end=\"982\">\u30c7\u30fc\u30bf\u89e3\u6790\uff1aFlowJo ver. 7.6.5<\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"984\" data-end=\"987\" \/>\n<h3 data-start=\"989\" data-end=\"1060\">Ad-GFP-DC\u306e\u8abf\u88fd\u3068\u751f\u4f53\u5185\u5206\u5e03\u8a55\u4fa1\uff08Preparation and biodistribution of Ad-GFP-DCs\uff09<\/h3>\n<ul data-start=\"1062\" data-end=\"1176\">\n<li data-start=\"1062\" data-end=\"1088\">\n<p data-start=\"1064\" data-end=\"1088\">BALB\/c\u30de\u30a6\u30b9\u306e\u5927\u817f\u9aa8\u304b\u3089BMDC\u3092\u63a1\u53d6<\/p>\n<\/li>\n<li data-start=\"1089\" data-end=\"1130\">\n<p data-start=\"1091\" data-end=\"1130\">GM-CSF\uff0840 ng\/mL\uff09\u3068IL-4\uff0810 ng\/mL\uff09\u30675\u65e5\u9593\u57f9\u990a<\/p>\n<\/li>\n<li data-start=\"1131\" data-end=\"1176\">\n<p data-start=\"1133\" data-end=\"1176\">\u8907\u88fd\u4e0d\u80fd\u306aAd-GFP\uff08MOI = 100\uff09\u30672\u65e5\u9593\u611f\u67d3 \u2192 Ad-GFP-DC\u3092\u5f97\u308b<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1178\" data-end=\"1190\"><strong data-start=\"1178\" data-end=\"1189\">\u751f\u4f53\u5185\u5206\u5e03\u8a66\u9a13<\/strong>\uff1a<\/p>\n<ul data-start=\"1192\" data-end=\"1285\">\n<li data-start=\"1192\" data-end=\"1228\">\n<p data-start=\"1194\" data-end=\"1228\">\u30de\u30a6\u30b9\u5de6\u8db3\u5e95\u306bAd-GFP-DC\u307e\u305f\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30ebDC\u3092\u76ae\u4e0b\u6295\u4e0e<\/p>\n<\/li>\n<li data-start=\"1229\" data-end=\"1258\">\n<p data-start=\"1231\" data-end=\"1258\">24\u6642\u9593\u5f8c\u3001\u5de6\u9f20\u5f84\u30ea\u30f3\u30d1\u7bc0\u3092\u6458\u51fa\u3057\u3001\u51cd\u7d50\u5207\u7247\u3092\u4f5c\u88fd<\/p>\n<\/li>\n<li data-start=\"1259\" data-end=\"1285\">\n<p data-start=\"1261\" data-end=\"1285\">\u9855\u5fae\u93e1\uff1aIX83\uff08Olympus\uff09\u306b\u3088\u308b\u86cd\u5149\u89b3\u5bdf<\/p>\n<\/li>\n<\/ul>\n<h3 data-start=\"51\" data-end=\"75\">\u7d30\u80de\u751f\u5b58\u7387\u30a2\u30c3\u30bb\u30a4\uff08XTT assay\uff09<\/h3>\n<ul data-start=\"77\" data-end=\"311\">\n<li data-start=\"77\" data-end=\"171\">\n<p data-start=\"79\" data-end=\"171\">OBP-702\uff08\u307e\u305f\u306fOBP-301\uff09\u3092\u3001<strong data-start=\"100\" data-end=\"108\">CT26<\/strong>\u307e\u305f\u306f<strong data-start=\"111\" data-end=\"121\">MC38\u7d30\u80de<\/strong>\u306b\u3055\u307e\u3056\u307e\u306aMOI\uff08Multiplicity of Infection\uff09\u3067\u611f\u67d3\u3055\u305b\u300172\u6642\u9593\u57f9\u990a<\/p>\n<\/li>\n<li data-start=\"172\" data-end=\"275\">\n<p data-start=\"174\" data-end=\"275\">\u7d30\u80de\u751f\u5b58\u7387\u306f\u3001<strong data-start=\"181\" data-end=\"192\">XTT\u30a2\u30c3\u30bb\u30a4<\/strong>\u3092\u7528\u3044\u3066\u6e2c\u5b9a\uff1a<br data-start=\"199\" data-end=\"202\" \/><br \/>\n\u3000- \u8a66\u85ac\uff1aCell Proliferation Kit II\uff08Roche\uff09<br data-start=\"240\" data-end=\"243\" \/><br \/>\n\u3000- \u5438\u5149\u5ea6\u6e2c\u5b9a\uff1a450 nm\u3067\u6e2c\u5b9a\uff08\u57fa\u6e96\u6ce2\u9577650 nm\uff09<\/p>\n<\/li>\n<li data-start=\"276\" data-end=\"311\">\n<p data-start=\"278\" data-end=\"311\">\u751f\u5b58\u7387\u306f\u3001\u672a\u611f\u67d3\u7d30\u80de\u3092100%\u3068\u3057\u3066\u76f8\u5bfe\u7684\u306b\u7b97\u51fa\uff08\u56f32A\u3001\u56f36A\uff09<\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"313\" data-end=\"316\" \/>\n<h3 data-start=\"318\" data-end=\"351\">\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u89e3\u6790\uff08Western blotting\uff09<\/h3>\n<ul data-start=\"353\" data-end=\"650\">\n<li data-start=\"353\" data-end=\"409\">\n<p data-start=\"355\" data-end=\"409\">\u611f\u67d3\u5f8c24\u6642\u9593\u306e<strong data-start=\"363\" data-end=\"371\">CT26<\/strong>\u307e\u305f\u306f<strong data-start=\"374\" data-end=\"384\">MC38\u7d30\u80de<\/strong>\u3092\u53ce\u96c6\u3057\u3001RIPA\u30d0\u30c3\u30d5\u30a1\u30fc\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u62bd\u51fa<\/p>\n<\/li>\n<li data-start=\"410\" data-end=\"435\">\n<p data-start=\"412\" data-end=\"435\">SDS-PAGE\u3067\u5206\u96e2\u5f8c\u3001PVDF\u819c\u3078\u8ee2\u5199<\/p>\n<\/li>\n<li data-start=\"436\" data-end=\"527\">\n<p data-start=\"438\" data-end=\"527\">\u4e00\u6b21\u6297\u4f53\uff1a<br data-start=\"443\" data-end=\"446\" \/><br \/>\n\u3000- \u30d2\u30c8p53\uff08DO-1, 1:500, Cell Signaling Technology\uff09<br data-start=\"494\" data-end=\"497\" \/><br \/>\n\u3000- GAPDH\uff081:1000, Santa Cruz\uff09<\/p>\n<\/li>\n<li data-start=\"528\" data-end=\"549\">\n<p data-start=\"530\" data-end=\"549\">\u4e8c\u6b21\u6297\u4f53\uff1aHRP\u7d50\u5408\u6297\u30de\u30a6\u30b9IgG<\/p>\n<\/li>\n<li data-start=\"550\" data-end=\"584\">\n<p data-start=\"552\" data-end=\"584\">\u767a\u8272\u691c\u51fa\uff1aECL\u30b7\u30b9\u30c6\u30e0\uff08GE Healthcare\uff09\u3092\u4f7f\u7528<\/p>\n<\/li>\n<li data-start=\"585\" data-end=\"650\">\n<p data-start=\"587\" data-end=\"650\">\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u88c5\u7f6e\uff1aImageQuant LAS 4000\uff08GE Healthcare\uff09\u307e\u305f\u306fChemiDoc\uff08Bio-Rad\uff09<\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"652\" data-end=\"655\" \/>\n<h3 data-start=\"657\" data-end=\"682\">\u30de\u30a6\u30b9\u76ae\u4e0b\u816b\u760d\u30e2\u30c7\u30eb\u3068\u6cbb\u7642\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb<\/h3>\n<p data-start=\"683\" data-end=\"739\">\uff08Mouse subcutaneous tumor models and treatment schedule\uff09<\/p>\n<p data-start=\"741\" data-end=\"754\"><strong data-start=\"741\" data-end=\"753\">\u816b\u760d\u30e2\u30c7\u30eb\u306e\u4f5c\u6210<\/strong>\uff1a<\/p>\n<ul data-start=\"756\" data-end=\"847\">\n<li data-start=\"756\" data-end=\"847\">\n<p data-start=\"758\" data-end=\"847\">BALB\/c\u307e\u305f\u306fC57BL\/6J\u30de\u30a6\u30b9\u306e\u53f3\u80cc\u90e8\u76ae\u4e0b\u306b\uff1a<br data-start=\"786\" data-end=\"789\" \/><br \/>\n\u3000- **CT26\u7d30\u80de\uff081\u00d710\u2076\u500b\uff09**\u307e\u305f\u306f<br data-start=\"813\" data-end=\"816\" \/><br \/>\n\u3000- **MC38\u7d30\u80de\uff085\u00d710\u2075\u500b\uff09**\u3092\u6ce8\u5c04\u3057\u3066\u816b\u760d\u3092\u5f62\u6210<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"849\" data-end=\"862\"><strong data-start=\"849\" data-end=\"861\">\u6cbb\u7642\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb<\/strong>\uff1a<\/p>\n<ol data-start=\"864\" data-end=\"1026\">\n<li data-start=\"864\" data-end=\"950\">\n<p data-start=\"867\" data-end=\"950\"><strong data-start=\"867\" data-end=\"879\">DC\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e<\/strong>\uff1a<br data-start=\"880\" data-end=\"883\" \/><br \/>\n\u3000- Day \u221221, \u221214, \u22127 \u306bAd-p53 DC\u307e\u305f\u306fDL312 DC\u3092\u76ae\u4e0b\u6ce8\uff08\u8db3\u5e95\uff09<br data-start=\"932\" data-end=\"935\" \/><br \/>\n\u3000- Day +6 \u306b\u8ffd\u52a0\u63a5\u7a2e<\/p>\n<\/li>\n<li data-start=\"952\" data-end=\"1026\">\n<p data-start=\"955\" data-end=\"1026\"><strong data-start=\"955\" data-end=\"976\">\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\uff08OBP-702\u306a\u3069\uff09<\/strong>\uff1a<br data-start=\"977\" data-end=\"980\" \/><br \/>\n\u3000- Day +7 \u304a\u3088\u3073 Day +10 \u306b\u3001\u816b\u760d\u5185\u3078\u30a6\u30a4\u30eb\u30b9\uff081\u00d710\u2078 PFU\uff09\u3092\u6ce8\u5c04<\/p>\n<\/li>\n<\/ol>\n<p data-start=\"1028\" data-end=\"1044\"><strong data-start=\"1028\" data-end=\"1043\">\u30a2\u30d6\u30b9\u30b3\u30d1\u30eb\u52b9\u679c\u306e\u691c\u8a3c<\/strong>\uff1a<\/p>\n<ul data-start=\"1046\" data-end=\"1107\">\n<li data-start=\"1046\" data-end=\"1107\">\n<p data-start=\"1048\" data-end=\"1107\">\u4e21\u5074\u816b\u760d\u30e2\u30c7\u30eb\uff1a<br data-start=\"1056\" data-end=\"1059\" \/><br \/>\n\u3000- \u53f3\u5074\u816b\u760d\uff1a\u6cbb\u7642\u5b9f\u65bd\uff08\u30a6\u30a4\u30eb\u30b9\u307e\u305f\u306fDC\uff09<br data-start=\"1082\" data-end=\"1085\" \/><br \/>\n\u3000- \u5de6\u5074\u816b\u760d\uff1a\u672a\u6cbb\u7642\u3068\u3057\u3066\u52b9\u679c\u306e\u6ce2\u53ca\u3092\u8a55\u4fa1<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1109\" data-end=\"1137\"><strong data-start=\"1109\" data-end=\"1136\">\u518d\u6311\u6226\u5b9f\u9a13\uff08Rechallenge test\uff09<\/strong>\uff1a<\/p>\n<ul data-start=\"1139\" data-end=\"1210\">\n<li data-start=\"1139\" data-end=\"1210\">\n<p data-start=\"1141\" data-end=\"1210\">\u5b8c\u5168\u594f\u52b9\uff08CR\uff09\u3092\u793a\u3057\u305f\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\uff1a<br data-start=\"1161\" data-end=\"1164\" \/><br \/>\n\u3000- CT26\u7d30\u80de\uff08\u53f3\u5074\uff09\u30014T1\u7d30\u80de\uff08\u5de6\u5074\uff09\u3092\u540c\u6642\u76ae\u4e0b\u63a5\u7a2e<br data-start=\"1194\" data-end=\"1197\" \/><br \/>\n\u3000- \u816b\u760d\u5f62\u6210\u306e\u6709\u7121\u3092\u89b3\u5bdf<\/p>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3 data-start=\"55\" data-end=\"92\">\u514d\u75ab\u7d44\u7e54\u5316\u5b66\uff08Immunohistochemistry, IHC\uff09<\/h3>\n<ul data-start=\"94\" data-end=\"355\">\n<li data-start=\"94\" data-end=\"129\">\n<p data-start=\"96\" data-end=\"129\">\u816b\u760d\u3092\u6458\u51fa\u5f8c\u30014%\u30d1\u30e9\u30db\u30eb\u30e0\u30a2\u30eb\u30c7\u30d2\u30c9\u3067\u56fa\u5b9a\u3057\u3001\u30d1\u30e9\u30d5\u30a3\u30f3\u5305\u57cb<\/p>\n<\/li>\n<li data-start=\"130\" data-end=\"178\">\n<p data-start=\"132\" data-end=\"178\">5 \u00b5m\u539a\u306e\u30b9\u30e9\u30a4\u30c9\u3092\u4f5c\u88fd\u3057\u3001\u6297\u539f\u8ce6\u6d3b\u51e6\u7406\uff08Tris-EDTA\u7de9\u885d\u6db2\u4e2d\u3067\u52a0\u71b1\u51e6\u7406\uff09\u3092\u5b9f\u65bd<\/p>\n<\/li>\n<li data-start=\"179\" data-end=\"256\">\n<p data-start=\"181\" data-end=\"256\">\u4e3b\u306a\u4e00\u6b21\u6297\u4f53\uff1a<br data-start=\"188\" data-end=\"191\" \/><br \/>\n\u3000- CD8\uff081:100\u3001Cell Signaling Technology\uff09<br data-start=\"230\" data-end=\"233\" \/><br \/>\n\u3000- CD11c\uff081:100\u3001Abcam\uff09<\/p>\n<\/li>\n<li data-start=\"257\" data-end=\"279\">\n<p data-start=\"259\" data-end=\"279\">\u4e8c\u6b21\u6297\u4f53\uff1aHRP\u6a19\u8b58\u6297\u30e9\u30d3\u30c3\u30c8IgG<\/p>\n<\/li>\n<li data-start=\"280\" data-end=\"306\">\n<p data-start=\"282\" data-end=\"306\">\u767a\u8272\uff1aDAB\uff083,3&#8242;-\u30b8\u30a2\u30df\u30ce\u30d9\u30f3\u30b8\u30b8\u30f3\uff09<\/p>\n<\/li>\n<li data-start=\"307\" data-end=\"328\">\n<p data-start=\"309\" data-end=\"328\">\u30ab\u30a6\u30f3\u30bf\u30fc\u30b9\u30c6\u30a4\u30f3\uff1a\u30d8\u30de\u30c8\u30ad\u30b7\u30ea\u30f3<\/p>\n<\/li>\n<li data-start=\"329\" data-end=\"355\">\n<p data-start=\"331\" data-end=\"355\">\u89b3\u5bdf\uff1a\u30aa\u30ea\u30f3\u30d1\u30b9IX83\u9855\u5fae\u93e1\uff08Olympus\uff09<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"357\" data-end=\"403\">\u203b CD8\u207aT\u7d30\u80de\u304a\u3088\u3073CD11c\u207aDC\u306e\u816b\u760d\u5185\u6d78\u6f64\u3092\u5b9a\u91cf\u7684\u306b\u8a55\u4fa1\uff08\u56f33A\u30fbB\u3001\u56f36H\u30fbI\uff09<\/p>\n<hr data-start=\"405\" data-end=\"408\" \/>\n<h3 data-start=\"410\" data-end=\"431\">IFN-\u03b3 ELISPOT\u30a2\u30c3\u30bb\u30a4<\/h3>\n<ul data-start=\"433\" data-end=\"655\">\n<li data-start=\"433\" data-end=\"486\">\n<p data-start=\"435\" data-end=\"486\">\u30de\u30a6\u30b9\u813e\u81d3\u7531\u6765\u5358\u6838\u7d30\u80de\uff08splenocytes\uff09\u3092IL-2\uff0810 ng\/mL\uff09\u3068\u3068\u3082\u306b72\u6642\u9593\u523a\u6fc0<\/p>\n<\/li>\n<li data-start=\"487\" data-end=\"518\">\n<p data-start=\"489\" data-end=\"518\">\u5408\u6210p53\u30da\u30d7\u30c1\u30c9\u30df\u30c3\u30af\u30b9\uff08\u54045 \u03bcg\/mL\uff09\u3068\u5171\u57f9\u990a<\/p>\n<\/li>\n<li data-start=\"519\" data-end=\"563\">\n<p data-start=\"521\" data-end=\"563\">IFN-\u03b3\u7523\u751f\u7d30\u80de\u306e\u6e2c\u5b9a\uff1aELISPOT\u30d7\u30ec\u30fc\u30c8\uff08R&amp;D Systems\uff09\u3092\u4f7f\u7528<\/p>\n<\/li>\n<li data-start=\"564\" data-end=\"616\">\n<p data-start=\"566\" data-end=\"616\">\u30d7\u30ec\u30fc\u30c8\u6d17\u6d44\u5f8c\u3001\u30d3\u30aa\u30c1\u30f3\u5316\u6297IFN-\u03b3\u6297\u4f53\u2192\u30b9\u30c8\u30ec\u30d7\u30c8\u30a2\u30d3\u30b8\u30f3-HRP\u2192\u767a\u8272\u57fa\u8cea\uff08AEC\uff09\u3067\u67d3\u8272<\/p>\n<\/li>\n<li data-start=\"617\" data-end=\"655\">\n<p data-start=\"619\" data-end=\"655\">\u30b9\u30dd\u30c3\u30c8\u6570\uff08IFN-\u03b3\u7523\u751f\u7d30\u80de\u6570\uff09\u3092\u753b\u50cf\u89e3\u6790\u88c5\u7f6e\u3067\u81ea\u52d5\u30ab\u30a6\u30f3\u30c8\uff08\u56f35C\uff09<\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"657\" data-end=\"660\" \/>\n<h3 data-start=\"662\" data-end=\"697\">\u514d\u75ab\u30da\u30d7\u30c1\u30c9\u30aa\u30df\u30af\u30b9\u89e3\u6790\uff08Immunopeptidomics\uff09<\/h3>\n<p data-start=\"699\" data-end=\"731\">\u76ee\u7684\uff1aMHC\u30af\u30e9\u30b9I\u304a\u3088\u3073II\u306b\u7d50\u5408\u3057\u305fp53\u7531\u6765\u30da\u30d7\u30c1\u30c9\u306e\u540c\u5b9a<\/p>\n<p data-start=\"733\" data-end=\"736\">\u624b\u9806\uff1a<\/p>\n<ol data-start=\"738\" data-end=\"1071\">\n<li data-start=\"738\" data-end=\"847\">\n<p data-start=\"741\" data-end=\"847\"><strong data-start=\"741\" data-end=\"749\">\u7d30\u80de\u8abf\u88fd<\/strong>\uff1a<br data-start=\"750\" data-end=\"753\" \/><br \/>\n\u3000- CT26\u7d30\u80de\uff08\u672a\u611f\u67d3\u3001OBP-301\u611f\u67d3\u3001OBP-702\u611f\u67d3\uff09<br data-start=\"787\" data-end=\"790\" \/><br \/>\n\u3000- MC38\u7d30\u80de\uff08\u672a\u611f\u67d3\u3001OBP-702\u611f\u67d3\uff09<br data-start=\"814\" data-end=\"817\" \/><br \/>\n\u3000- DC\uff08\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3001DL312\u611f\u67d3\u3001Ad-p53\u611f\u67d3\uff09<\/p>\n<\/li>\n<li data-start=\"849\" data-end=\"888\">\n<p data-start=\"852\" data-end=\"888\"><strong data-start=\"852\" data-end=\"870\">MHC-I\/II\u8907\u5408\u4f53\u306e\u5358\u96e2<\/strong>\uff1a<br data-start=\"871\" data-end=\"874\" \/><br \/>\n\u3000- \u6297MHC\u6297\u4f53\u3067\u514d\u75ab\u6c88\u964d<\/p>\n<\/li>\n<li data-start=\"890\" data-end=\"1071\">\n<p data-start=\"893\" data-end=\"1071\"><strong data-start=\"893\" data-end=\"914\">\u30da\u30d7\u30c1\u30c9\u62bd\u51fa\u3068LC-MS\/MS\u89e3\u6790<\/strong>\uff1a<br data-start=\"915\" data-end=\"918\" \/><br \/>\n\u3000- \u9178\u51e6\u7406\u3067MHC\u304b\u3089\u30da\u30d7\u30c1\u30c9\u3092\u6eb6\u51fa<br data-start=\"937\" data-end=\"940\" \/><br \/>\n\u3000- LC-MS\/MS\uff08\u30ca\u30ce\u6db2\u4f53\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\uff0b\u8cea\u91cf\u5206\u6790\uff09\u3067\u5206\u6790<br data-start=\"974\" data-end=\"977\" \/><br \/>\n\u3000- \u30c7\u30fc\u30bf\u89e3\u6790\uff1aSpectrum Mill\u304a\u3088\u3073UniProt\u30bf\u30f3\u30d1\u30af\u8cea\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u4f7f\u7528<br data-start=\"1022\" data-end=\"1025\" \/><br \/>\n\u3000- \u30de\u30a6\u30b9\u3068\u30d2\u30c8p53\u914d\u5217\u306e<strong data-start=\"1040\" data-end=\"1051\">\u4e00\u81f4\u9818\u57df\u306b\u9650\u308a<\/strong>\u691c\u7d22\u5bfe\u8c61\u3068\u3059\u308b\uff08p53\u7279\u7570\u6027\u62c5\u4fdd\u306e\u305f\u3081\uff09<\/p>\n<\/li>\n<\/ol>\n<p data-start=\"1073\" data-end=\"1109\">\u5f97\u3089\u308c\u305f\u30da\u30d7\u30c1\u30c9\u306f\u88dc\u8db3\u88681\u306b\u4e00\u89a7\u5316\uff08\u4f8b\uff1aAPRMPEAAPPVAP\u306a\u3069\uff09<\/p>\n<hr data-start=\"1111\" data-end=\"1114\" \/>\n<p data-start=\"1116\" data-end=\"1190\" data-is-last-node=\"\" data-is-only-node=\"\">\u6b21\u56de\u306f\u3010Cytotoxicity assay\uff08\u7d30\u80de\u50b7\u5bb3\u6027\u30a2\u30c3\u30bb\u30a4\uff09\u3011\u3068\u3010\u7d71\u8a08\u89e3\u6790\u3011\u306e\u90a6\u8a33\u3067\u300c\u6750\u6599\u3068\u65b9\u6cd5\u300d\u306e\u5b8c\u4e86\u3068\u306a\u308a\u307e\u3059\u3002\u7d9a\u3051\u3066\u3088\u308d\u3057\u3044\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p data-start=\"1116\" data-end=\"1190\" data-is-last-node=\"\" data-is-only-node=\"\">\u00a0<\/p>\n<h3 data-start=\"73\" data-end=\"106\">\u7d30\u80de\u50b7\u5bb3\u6027\u30a2\u30c3\u30bb\u30a4\uff08Cytotoxicity assay\uff09<\/h3>\n<p data-start=\"108\" data-end=\"168\">\u76ee\u7684\uff1aAd-p53 DC\uff0bOBP-702\u4f75\u7528\u7642\u6cd5\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b<strong data-start=\"141\" data-end=\"165\">CD8\u207aT\u7d30\u80de\u306e\u816b\u760d\u7d30\u80de\u306b\u5bfe\u3059\u308b\u6bba\u50b7\u6d3b\u6027<\/strong>\u3092\u6e2c\u5b9a<\/p>\n<p data-start=\"170\" data-end=\"173\">\u624b\u9806\uff1a<\/p>\n<ol data-start=\"175\" data-end=\"651\">\n<li data-start=\"175\" data-end=\"280\">\n<p data-start=\"178\" data-end=\"280\"><strong data-start=\"178\" data-end=\"188\">T\u7d30\u80de\u306e\u8a98\u5c0e<\/strong>\uff1a<br data-start=\"189\" data-end=\"192\" \/><br \/>\n\u3000- Ad-p53 DCs\uff0bOBP-702\u4f75\u7528\u7642\u6cd5\u3092\u53d7\u3051\u305f\u30de\u30a6\u30b9\u3001\u304a\u3088\u3073\u5bfe\u7167\u30de\u30a6\u30b9\u304b\u3089\u813e\u7d30\u80de\u3092\u63a1\u53d6<br data-start=\"241\" data-end=\"244\" \/><br \/>\n\u3000- IL-2\uff0810 ng\/mL\uff09\u30677\u65e5\u9593\u523a\u6fc0\u3057\u3066CD8\u207aT\u7d30\u80de\u3092\u6d3b\u6027\u5316<\/p>\n<\/li>\n<li data-start=\"282\" data-end=\"370\">\n<p data-start=\"285\" data-end=\"370\"><strong data-start=\"285\" data-end=\"296\">\u6a19\u7684\u7d30\u80de\u306e\u6e96\u5099<\/strong>\uff1a<br data-start=\"297\" data-end=\"300\" \/><br \/>\n\u3000- <strong data-start=\"303\" data-end=\"313\">MC38\u7d30\u80de<\/strong>\u309250 Gy\u3067\u03b3\u7dda\u7167\u5c04\uff08\u6b7b\u7d30\u80de\u306b\u3088\u308b\u80cc\u666f\u4f4e\u6e1b\u306e\u305f\u3081\uff09<br data-start=\"339\" data-end=\"342\" \/><br \/>\n\u3000- 96\u30a6\u30a7\u30eb\u30d7\u30ec\u30fc\u30c8\u306b\u64ad\u7a2e\uff081\u00d710\u2074\u7d30\u80de\/\u30a6\u30a7\u30eb\uff09<\/p>\n<\/li>\n<li data-start=\"372\" data-end=\"441\">\n<p data-start=\"375\" data-end=\"441\"><strong data-start=\"375\" data-end=\"382\">\u5171\u57f9\u990a<\/strong>\uff1a<br data-start=\"383\" data-end=\"386\" \/><br \/>\n\u3000- Effector\uff08T\u7d30\u80de\uff09\u3068Target\uff08\u816b\u760d\u7d30\u80de\uff09\u3092 <strong data-start=\"417\" data-end=\"432\">E:T\u6bd4 = 10:1<\/strong> \u306724\u6642\u9593\u5171\u57f9\u990a<\/p>\n<\/li>\n<li data-start=\"443\" data-end=\"651\">\n<p data-start=\"446\" data-end=\"651\"><strong data-start=\"446\" data-end=\"457\">LDH\u30a2\u30c3\u30bb\u30a4<\/strong>\u306b\u3088\u308b\u7d30\u80de\u969c\u5bb3\u8a55\u4fa1\uff1a<br data-start=\"467\" data-end=\"470\" \/><br \/>\n\u3000- \u4e0a\u6e05\u4e2d\u306e<strong data-start=\"477\" data-end=\"495\">\u4e73\u9178\u8131\u6c34\u7d20\u9175\u7d20\uff08LDH\uff09\u6d3b\u6027<\/strong>\u3092\u6e2c\u5b9a\uff08CytoTox 96 Non-Radioactive Cytotoxicity Assay Kit, Promega\uff09<br data-start=\"558\" data-end=\"561\" \/><br \/>\n\u3000- \u5438\u5149\u5ea6\uff1a490 nm<br data-start=\"574\" data-end=\"577\" \/><br \/>\n\u3000- \u7d30\u80de\u6eb6\u89e3\u7387\uff08%\uff09\u306f\u4ee5\u4e0b\u3067\u7b97\u51fa\uff1a<br data-start=\"595\" data-end=\"598\" \/><br \/>\n\u3000\u3000<strong data-start=\"600\" data-end=\"651\">(\u5b9f\u9a13LDH \u2212 \u30b9\u30dd\u30f3\u30c6\u30a4\u30f3LDH) \/ (\u6700\u5927LDH \u2212 \u30b9\u30dd\u30f3\u30c6\u30a4\u30f3LDH) \u00d7 100<\/strong><\/p>\n<\/li>\n<\/ol>\n<hr data-start=\"653\" data-end=\"656\" \/>\n<h3 data-start=\"658\" data-end=\"688\">\u7d71\u8a08\u89e3\u6790\uff08Statistical analysis\uff09<\/h3>\n<ul data-start=\"690\" data-end=\"961\">\n<li data-start=\"690\" data-end=\"727\">\n<p data-start=\"692\" data-end=\"727\">\u3059\u3079\u3066\u306e\u6570\u5024\u30c7\u30fc\u30bf\u306f <strong data-start=\"703\" data-end=\"721\">\u5e73\u5747 \u00b1 \u6a19\u6e96\u8aa4\u5dee\uff08SEM\uff09<\/strong> \u3067\u8868\u8a18<\/p>\n<\/li>\n<li data-start=\"728\" data-end=\"762\">\n<p data-start=\"730\" data-end=\"762\">\u7d71\u8a08\u30bd\u30d5\u30c8\uff1a<strong data-start=\"736\" data-end=\"756\">GraphPad Prism 9<\/strong> \u3092\u4f7f\u7528<\/p>\n<\/li>\n<li data-start=\"763\" data-end=\"848\">\n<p data-start=\"765\" data-end=\"848\">\u6bd4\u8f03\u65b9\u6cd5\uff1a<br data-start=\"770\" data-end=\"773\" \/><br \/>\n\u3000- <strong data-start=\"776\" data-end=\"783\">2\u7fa4\u9593<\/strong>\uff1a\u975e\u5bfe\u5fdc <strong data-start=\"788\" data-end=\"795\">t\u691c\u5b9a<\/strong><br data-start=\"795\" data-end=\"798\" \/><br \/>\n\u3000- <strong data-start=\"801\" data-end=\"809\">\u8907\u6570\u7fa4\u9593<\/strong>\uff1a<strong data-start=\"810\" data-end=\"829\">\u4e00\u5143\u914d\u7f6e\u5206\u6563\u5206\u6790\uff08ANOVA\uff09<\/strong> \u2192 Dunnett\u306e\u591a\u91cd\u6bd4\u8f03\u691c\u5b9a<\/p>\n<\/li>\n<li data-start=\"849\" data-end=\"961\">\n<p data-start=\"851\" data-end=\"961\">\u6709\u610f\u6c34\u6e96\uff1a<br data-start=\"856\" data-end=\"859\" \/><br \/>\n\u3000- <em data-start=\"862\" data-end=\"865\">p<\/em> &lt; 0.05\uff1a\u6709\u610f\u5dee\u3042\u308a<br data-start=\"878\" data-end=\"881\" \/><br \/>\n\u3000- <strong data-start=\"884\" data-end=\"893\">\u8a18\u53f7\u306e\u5b9a\u7fa9<\/strong>\uff1a<br data-start=\"894\" data-end=\"897\" \/><br \/>\n\u3000\u3000- <em data-start=\"901\" data-end=\"904\">p<\/em> &lt; 0.05 \u2192 *<br data-start=\"915\" data-end=\"918\" \/><br \/>\n\u3000\u3000- <em data-start=\"922\" data-end=\"925\">p<\/em> &lt; 0.01 \u2192 **<br data-start=\"937\" data-end=\"940\" \/><br \/>\n\u3000\u3000- <em data-start=\"944\" data-end=\"947\">p<\/em> &lt; 0.001 \u2192 ***<\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"166\" data-end=\"182\">\u53c2\u8003\u6587\u732e\uff08\u524d\u534a 1\u201318\uff09<\/h2>\n<ol start=\"19\" data-start=\"71\" data-end=\"1864\">\n<li data-start=\"184\" data-end=\"275\">\n<p data-start=\"187\" data-end=\"275\"><strong data-start=\"187\" data-end=\"219\">Palucka, K. &amp; Banchereau, J.<\/strong><br data-start=\"219\" data-end=\"222\" \/><br \/>\n\u3000\u6a39\u72b6\u7d30\u80de\u30ef\u30af\u30c1\u30f3\u306b\u95a2\u3059\u308b\u7dcf\u8aac\u3002<br data-start=\"238\" data-end=\"241\" \/><br \/>\n\u3000Nat Rev Cancer 12, 265\u2013277 (2012)<\/p>\n<\/li>\n<li data-start=\"277\" data-end=\"388\">\n<p data-start=\"280\" data-end=\"388\"><strong data-start=\"280\" data-end=\"310\">Hegde, P. S. &amp; Chen, D. S.<\/strong><br data-start=\"310\" data-end=\"313\" \/><br \/>\n\u3000\u816b\u760d\u514d\u75ab\u306b\u304a\u3051\u308b\u514d\u75ab\u300c\u30db\u30c3\u30c8\u300d\u304a\u3088\u3073\u300c\u30b3\u30fc\u30eb\u30c9\u300d\u306e\u533a\u5225\u3068\u81e8\u5e8a\u7684\u610f\u7fa9\u3002<br data-start=\"348\" data-end=\"351\" \/><br \/>\n\u3000Clin Cancer Res 26, 4302\u20134308 (2020)<\/p>\n<\/li>\n<li data-start=\"390\" data-end=\"522\">\n<p data-start=\"393\" data-end=\"522\"><strong data-start=\"393\" data-end=\"423\">Suda, T. &amp; Wakabayashi, T.<\/strong><br data-start=\"423\" data-end=\"426\" \/><br \/>\n\u3000\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u7279\u7570\u7684\u816b\u760d\u6eb6\u89e3\u6027\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9OBP-301\uff08Telomelysin\uff09\u306e\u524d\u81e8\u5e8a\u30c7\u30fc\u30bf\u3002<br data-start=\"476\" data-end=\"479\" \/><br \/>\n\u3000Curr Cancer Drug Targets 8, 416\u2013425 (2008)<\/p>\n<\/li>\n<li data-start=\"524\" data-end=\"619\">\n<p data-start=\"527\" data-end=\"619\"><strong data-start=\"527\" data-end=\"546\">Sato, Y. et al.<\/strong><br data-start=\"546\" data-end=\"549\" \/><br \/>\n\u3000OBP-301\u306b\u3088\u308b\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u7279\u7570\u7684p53\u816b\u760d\u6291\u5236\u3002<br data-start=\"577\" data-end=\"580\" \/><br \/>\n\u3000Mol Ther Oncolytics 15, 180\u2013188 (2019)<\/p>\n<\/li>\n<li data-start=\"621\" data-end=\"719\">\n<p data-start=\"624\" data-end=\"719\"><strong data-start=\"624\" data-end=\"647\">Kitamura, T. et al.<\/strong><br data-start=\"647\" data-end=\"650\" \/><br \/>\n\u3000Ad-p53\u5c0e\u5165DC\u306b\u3088\u308b\u5927\u8178\u304c\u3093\u30e2\u30c7\u30eb\u306b\u5bfe\u3059\u308bT\u7d30\u80de\u5fdc\u7b54\u8a98\u5c0e\u3002<br data-start=\"683\" data-end=\"686\" \/><br \/>\n\u3000Cancer Sci 106, 1582\u20131590 (2015)<\/p>\n<\/li>\n<li data-start=\"721\" data-end=\"809\">\n<p data-start=\"724\" data-end=\"809\"><strong data-start=\"724\" data-end=\"742\">Ito, M. et al.<\/strong><br data-start=\"742\" data-end=\"745\" \/><br \/>\n\u3000\u540c\u4e0a\uff1aAd-p53 DC\u30ef\u30af\u30c1\u30f3\u306e\u514d\u75ab\u539f\u6027\u3068\u6297\u816b\u760d\u52b9\u679c\u3002<br data-start=\"774\" data-end=\"777\" \/><br \/>\n\u3000J Immunother 38, 292\u2013302 (2015)<\/p>\n<\/li>\n<li data-start=\"811\" data-end=\"894\">\n<p data-start=\"814\" data-end=\"894\"><strong data-start=\"814\" data-end=\"847\">Hanahan, D. &amp; Weinberg, R. 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M. et al.<\/strong><br data-start=\"1050\" data-end=\"1053\" \/><br \/>\n\u3000\u5316\u5b66\u7642\u6cd5\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u308b\u816b\u760d\u6297\u539f\u306e\u63d0\u793a\u3068\u514d\u75ab\u52b9\u679c\u3002<br data-start=\"1079\" data-end=\"1082\" \/><br \/>\n\u3000Nature 425, 305\u2013309 (2003)<\/p>\n<\/li>\n<li data-start=\"1111\" data-end=\"1218\">\n<p data-start=\"1115\" data-end=\"1218\"><strong data-start=\"1115\" data-end=\"1138\">Theobald, M. et al.<\/strong><br data-start=\"1138\" data-end=\"1141\" \/><br \/>\n\u3000HLA-A2\u62d8\u675f\u6027p53\u30da\u30d7\u30c1\u30c9\u306b\u5bfe\u3059\u308bCTL\u306e\u8a98\u5c0e\u3002<br data-start=\"1169\" data-end=\"1172\" \/><br \/>\n\u3000Proc Natl Acad Sci USA 92, 11993\u201311997 (1995)<\/p>\n<\/li>\n<li data-start=\"1220\" data-end=\"1306\">\n<p data-start=\"1224\" data-end=\"1306\"><strong data-start=\"1224\" data-end=\"1242\">Liu, Y. et al.<\/strong><br data-start=\"1242\" data-end=\"1245\" \/><br \/>\n\u3000\u653e\u5c04\u7dda\u6cbb\u7642\u5f8c\u306e\u30a2\u30d6\u30b9\u30b3\u30d1\u30eb\u52b9\u679c\u3068\u305d\u306e\u514d\u75ab\u5b66\u7684\u57fa\u76e4\u3002<br data-start=\"1271\" data-end=\"1274\" \/><br \/>\n\u3000Cancer Lett 356, 180\u2013190 (2015)<\/p>\n<\/li>\n<li data-start=\"1308\" data-end=\"1402\">\n<p data-start=\"1312\" data-end=\"1402\"><strong data-start=\"1312\" data-end=\"1335\">Yamamoto, M. et al.<\/strong><br data-start=\"1335\" data-end=\"1338\" \/><br \/>\n\u3000OBP-502\u306e\u514d\u75ab\u8a18\u61b6\u8a98\u5c0e\u3068\u30a2\u30d6\u30b9\u30b3\u30d1\u30eb\u52b9\u679c\u3002<br data-start=\"1363\" data-end=\"1366\" \/><br \/>\n\u3000Cancer Gene Ther 28, 173\u2013184 (2021)<\/p>\n<\/li>\n<li data-start=\"1404\" data-end=\"1498\">\n<p data-start=\"1408\" data-end=\"1498\"><strong data-start=\"1408\" data-end=\"1427\">Sato, Y. et al.<\/strong><br data-start=\"1427\" data-end=\"1430\" \/><br \/>\n\u3000\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u7279\u7570\u7684\u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\u306b\u3088\u308b\u514d\u75ab\u523a\u6fc0\u52b9\u679c\u3002<br data-start=\"1456\" data-end=\"1459\" \/><br \/>\n\u3000Mol Ther Oncolytics 27, 198\u2013208 (2022)<\/p>\n<\/li>\n<li data-start=\"1500\" data-end=\"1590\">\n<p data-start=\"1504\" data-end=\"1590\"><strong data-start=\"1504\" data-end=\"1527\">Sugawara, Y. et al.<\/strong><br data-start=\"1527\" data-end=\"1530\" \/><br \/>\n\u3000OBP-702\u306b\u3088\u308b\u816b\u760d\u5e38\u5728\u8a18\u61b6T\u7d30\u80de\u306e\u8a98\u5c0e\u3002<br data-start=\"1554\" data-end=\"1557\" \/><br \/>\n\u3000Cancer Sci 113, 3858\u20133869 (2022)<\/p>\n<\/li>\n<li data-start=\"1592\" data-end=\"1685\">\n<p data-start=\"1596\" data-end=\"1685\"><strong data-start=\"1596\" data-end=\"1619\">Kitamura, T. et al.<\/strong><br data-start=\"1619\" data-end=\"1622\" \/><br \/>\n\u3000\u816b\u760d\u5185\u6295\u4e0e\u306b\u3088\u308bAd-p53 DC\u306e\u6d3b\u6027\u5316\u52b9\u679c\u3002<br data-start=\"1647\" data-end=\"1650\" \/><br \/>\n\u3000Int J Cancer 145, 2420\u20132429 (2019)<\/p>\n<\/li>\n<li data-start=\"1687\" data-end=\"1774\">\n<p data-start=\"1691\" data-end=\"1774\"><strong data-start=\"1691\" data-end=\"1714\">Kitamura, T. et al.<\/strong><br data-start=\"1714\" data-end=\"1717\" \/><br \/>\n\u3000\u816b\u760d\u5185\u6ce8\u5c04\u306b\u3088\u308bDC\u6d3b\u6027\u5316\u3068T\u7d30\u80de\u52d5\u54e1\u3002<br data-start=\"1738\" data-end=\"1741\" \/><br \/>\n\u3000Cancer Sci 112, 3911\u20133921 (2021)<\/p>\n<\/li>\n<li data-start=\"1776\" data-end=\"1864\">\n<p data-start=\"1780\" data-end=\"1864\"><strong data-start=\"1780\" data-end=\"1802\">Hodi, F. S. et al.<\/strong><br data-start=\"1802\" data-end=\"1805\" \/><br \/>\n\u3000\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306e\u9032\u5c55\u3068\u4f75\u7528\u6226\u7565\u3002<br data-start=\"1828\" data-end=\"1831\" \/><br \/>\n\u3000N Engl J Med 363, 711\u2013723 (2010)<\/p>\n<\/li>\n<\/ol>\n<p>\uff08\u3068\u308a\u3042\u3048\u305a\u3053\u3053\u307e\u3067\uff09by \u30b7\u30a8\u30f3<\/p>\n<div class=\"pt-cv-wrapper\"><div class=\"pt-cv-view pt-cv-grid pt-cv-colsys pt-cv-post-border pt-cv-left\" id=\"pt-cv-view-15185e6rup\"><div data-id=\"pt-cv-page-1\" class=\"pt-cv-page\" data-cvc=\"1\"><div class=\"col-md-12 col-sm-12 col-xs-12 pt-cv-content-item pt-cv-2-col\"  data-pid=\"2483\"><div class='pt-cv-ifield'><h4 class=\"pt-cv-title\"><a href=\"http:\/\/m12n08.jp\/blog\/share\/4588oncolys\/2483.html\" class=\"_self cvplbd\" target=\"_self\" >4588\u30aa\u30f3\u30b3\u30ea\u30b9\u30d0\u30a4\u30aa\u30d5\u30a1\u30fc\u30de\u306e\u5c06\u6765\u6027\uff0f\u304c\u3093\u3092\u5207\u3089\u305a\u306b\u6cbb\u3059 \u30a6\u30a4\u30eb\u30b9\u7642\u6cd5\u30c6\u30ed\u30e1\u30e9\u30a4\u30b7\u30f3<\/a><\/h4>\n<a href=\"http:\/\/m12n08.jp\/blog\/share\/4588oncolys\/2483.html\" class=\"_self pt-cv-href-thumbnail pt-cv-thumb-left cvplbd\" target=\"_self\" ><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"120\" src=\"http:\/\/m12n08.jp\/blog\/wp-content\/uploads\/2019\/04\/2019-05-01_152331-200x120.png\" class=\"pt-cv-thumbnail img-shadow pull-left\" alt=\"\u30aa\u30f3\u30b3\u30ea\u30b9 \u30d3\u30b8\u30cd\u30b9\u30e2\u30c7\u30eb\" srcset=\"http:\/\/m12n08.jp\/blog\/wp-content\/uploads\/2019\/04\/2019-05-01_152331-200x120.png\" sizes=\"100vw\" wpfc-lazyload-disable=\"true\" \/><\/a>\n<div class=\"pt-cv-content\">\u3053\u3093\u306b\u3061\u306f\u3001\u30b7\u30a8\u30f3\uff08@m12n08.jp\uff09\u3067\u3059\u3002 \u3010\u672c\u30da\u30fc\u30b8\u306f2019\u5e744\u6708\u306b\u66f8\u3044\u305f\u8a18\u4e8b\u30922021\u5e741\u6708\u306b\u52a0\u7b46\u3057\u307e\u3057\u305f\u3011 2019\u5e7412\u670830\u65e5\uff08\u6708\uff09\u6642\u70b9\u30674588\u30aa\u30f3\u30b3\u30ea\u30b9\u309215,500\u682a\u4fdd\u6709\u3057\u3066\u3044\u307e\u3059\uff08\u5e73\u5747\u53d6\u5f97\u4fa1\u683c\u7d042,035\u5186\uff09\u3002 \u3082\u3057\u30aa\u30f3\u30b3\u30ea\u30b9\u306e\u682a\u4fa1\u304c30,000\u5186\u306b\u306a\u308c\u3070\u79c1\u306e\u682a\u8cc7\u7523\u306f4.65\u5104\u5186\u3068\u306a\u308a\u307e\u3059\u3002 \u306a\u308b\u3053\u3068\u306f\u9593\u9055\u3044\u306a\u3044\u3068\u500b\u4eba\u7684\u306b\u601d\u3063\u3066\u304a\u308a\u3001\u554f\u984c\u306f\u300c\u3044\u3064\u304b\u300d\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u30fb\u30fb\u30fb\u3002 \u3055<br \/><div class=\"pt-cv-rmwrap\"><a href=\"http:\/\/m12n08.jp\/blog\/share\/4588oncolys\/2483.html\" class=\"_self pt-cv-readmore btn btn-success cvplbd\" target=\"_self\">\uff1e\uff1e\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/div><\/div>\n<div class=\"pt-cv-meta-fields\"><span class=\"terms\"><span class=\"glyphicon glyphicon-folder-open\"><\/span> <a href='http:\/\/m12n08.jp\/blog\/.\/share\/4588oncolys' title='4588\u30aa\u30f3\u30b3\u30ea\u30b9' class='pt-cv-tax-4588oncolys'>4588\u30aa\u30f3\u30b3\u30ea\u30b9<\/a><\/span><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t<style type=\"text\/css\" id=\"pt-cv-inline-style-833eb25u9t\">#pt-cv-view-15185e6rup.pt-cv-post-border { margin: 0; border-top-width: 2px; border-left-width: 2px }\n#pt-cv-view-15185e6rup.pt-cv-post-border { margin: 0; border-top-style: groove; border-left-style: groove }\n#pt-cv-view-15185e6rup.pt-cv-post-border { margin: 0; border-top-color: #1122cc; border-left-color: #1122cc }\n#pt-cv-view-15185e6rup.pt-cv-post-border .pt-cv-content-item   { border-right-width: 2px; border-bottom-width: 2px; border-right-style: groove; border-bottom-style: groove; border-right-color: #1122cc; border-bottom-color: #1122cc; }\n#pt-cv-view-15185e6rup .pt-cv-title a, #pt-cv-view-15185e6rup  .panel-title { font-size: 15px !important; line-height: 1.3 !important; color: #1122cc !important; font-weight: 600 !important; }\n#pt-cv-view-15185e6rup  .pt-cv-title a:hover, #pt-cv-view-15185e6rup  .panel-title:hover   { color: #ff89ff !important; }\n#pt-cv-view-15185e6rup .pt-cv-meta-fields * { font-weight: 600 !important; }\n#pt-cv-view-15185e6rup .pt-cv-readmore  { color: #ffffff !important; background-color: #1122cc !important; }\n#pt-cv-view-15185e6rup .pt-cv-tao  { font-size: 20px !important; line-height: 1.3 !important; }\n#pt-cv-view-15185e6rup { text-align: left; }<\/style>\r\n\t\t\t\n<div class=\"pt-cv-wrapper\"><div class=\"pt-cv-view pt-cv-grid pt-cv-colsys pt-cv-post-border pt-cv-left\" id=\"pt-cv-view-46cddees9p\"><div data-id=\"pt-cv-page-1\" class=\"pt-cv-page\" data-cvc=\"1\"><div class=\"col-md-12 col-sm-12 col-xs-12 pt-cv-content-item pt-cv-2-col\"  data-pid=\"3061\"><div class='pt-cv-ifield'><h4 class=\"pt-cv-title\"><a href=\"http:\/\/m12n08.jp\/blog\/share\/4588oncolys\/3061.html\" class=\"_self cvplbd\" target=\"_self\" >4588\u30aa\u30f3\u30b3\u30ea\u30b9\u3092\u9577\u671f\u4fdd\u6709\u3059\u308b\u305f\u3081\u306e\u77e5\u8b58\u30fb\u8cc7\u6599<\/a><\/h4>\n<a href=\"http:\/\/m12n08.jp\/blog\/share\/4588oncolys\/3061.html\" class=\"_self pt-cv-href-thumbnail pt-cv-thumb-left cvplbd\" target=\"_self\" ><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"120\" src=\"http:\/\/m12n08.jp\/blog\/wp-content\/uploads\/2020\/06\/2021-01-24_164006-200x120.png\" class=\"pt-cv-thumbnail img-shadow pull-left\" alt=\"\u30aa\u30f3\u30b3\u30ea\u30b9\u30d0\u30a4\u30aa\u30d5\u30a1\u30fc\u30de \u30c6\u30ed\u30e1\u30e9\u30a4\u30b7\u30f3 \u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u4e00\u89a7 \u5c06\u6765\u6027\" srcset=\"http:\/\/m12n08.jp\/blog\/wp-content\/uploads\/2020\/06\/2021-01-24_164006-200x120.png\" sizes=\"100vw\" wpfc-lazyload-disable=\"true\" \/><\/a>\n<div class=\"pt-cv-content\">\u3053\u3093\u306b\u3061\u306f\u3001\u30b7\u30a8\u30f3\uff08@M12n08Jp)\u3067\u3059\u3002 \u3053\u306e\u30da\u30fc\u30b8\u3067\u306f4588\u30aa\u30f3\u30b3\u30ea\u30b9\u30d0\u30a4\u30aa\u30d5\u30a1\u30fc\u30de\u95a2\u9023\u3067\u545f\u3044\u305f\u8cc7\u6599\u3092\u4e2d\u5fc3\u306b\u30aa\u30f3\u30b3\u30ea\u30b9\u793e\u306e<br \/><div class=\"pt-cv-rmwrap\"><a href=\"http:\/\/m12n08.jp\/blog\/share\/4588oncolys\/3061.html\" class=\"_self pt-cv-readmore btn btn-success cvplbd\" target=\"_self\">\uff1e\uff1e\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/div><\/div>\n<div class=\"pt-cv-meta-fields\"><span class=\"terms\"><span class=\"glyphicon glyphicon-folder-open\"><\/span> <a href='http:\/\/m12n08.jp\/blog\/.\/share\/4588oncolys' title='4588\u30aa\u30f3\u30b3\u30ea\u30b9' class='pt-cv-tax-4588oncolys'>4588\u30aa\u30f3\u30b3\u30ea\u30b9<\/a><\/span><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t<style type=\"text\/css\" id=\"pt-cv-inline-style-50f83a3h6n\">#pt-cv-view-46cddees9p.pt-cv-post-border { margin: 0; border-top-width: 2px; border-left-width: 2px }\n#pt-cv-view-46cddees9p.pt-cv-post-border { margin: 0; border-top-style: groove; border-left-style: groove }\n#pt-cv-view-46cddees9p.pt-cv-post-border { margin: 0; border-top-color: #1122cc; border-left-color: #1122cc }\n#pt-cv-view-46cddees9p.pt-cv-post-border .pt-cv-content-item   { border-right-width: 2px; border-bottom-width: 2px; border-right-style: groove; border-bottom-style: groove; border-right-color: #1122cc; border-bottom-color: #1122cc; }\n#pt-cv-view-46cddees9p .pt-cv-title a, #pt-cv-view-46cddees9p  .panel-title { font-size: 15px !important; line-height: 1.3 !important; color: #1122cc !important; font-weight: 600 !important; }\n#pt-cv-view-46cddees9p  .pt-cv-title a:hover, #pt-cv-view-46cddees9p  .panel-title:hover   { color: #ff89ff !important; }\n#pt-cv-view-46cddees9p .pt-cv-meta-fields * { font-weight: 600 !important; }\n#pt-cv-view-46cddees9p .pt-cv-readmore  { color: #ffffff !important; background-color: #1122cc !important; }\n#pt-cv-view-46cddees9p .pt-cv-tao  { font-size: 20px !important; line-height: 1.3 !important; }\n#pt-cv-view-46cddees9p { text-align: left; }<\/style>\r\n\t\t\t\n<div class=\"pt-cv-wrapper\"><div class=\"pt-cv-view pt-cv-grid pt-cv-colsys pt-cv-post-border pt-cv-left\" id=\"pt-cv-view-5db66d9qdh\"><div data-id=\"pt-cv-page-1\" class=\"pt-cv-page\" data-cvc=\"1\"><div class=\"col-md-12 col-sm-12 col-xs-12 pt-cv-content-item pt-cv-2-col\"  data-pid=\"2887\"><div class='pt-cv-ifield'><h4 class=\"pt-cv-title\"><a href=\"http:\/\/m12n08.jp\/blog\/share\/4588oncolys\/2887.html\" class=\"_self cvplbd\" target=\"_self\" >4588\u30aa\u30f3\u30b3\u30ea\u30b9\u30d0\u30a4\u30aa\u30d5\u30a1\u30fc\u30de\uff0f2013\u5e74\u4e0a\u5834\u6642\u306e\u6d66\u7530\u793e\u9577\u30a4\u30f3\u30bf\u30d3\u30e5\u30fc<\/a><\/h4>\n<a href=\"http:\/\/m12n08.jp\/blog\/share\/4588oncolys\/2887.html\" class=\"_self pt-cv-href-thumbnail pt-cv-thumb-left cvplbd\" target=\"_self\" ><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"120\" src=\"http:\/\/m12n08.jp\/blog\/wp-content\/uploads\/2019\/12\/2019-12-22_171820-200x120.png\" class=\"pt-cv-thumbnail img-shadow pull-left\" alt=\"\u30aa\u30f3\u30b3\u30ea\u30b9 \u30c6\u30ed\u30e1\u30e9\u30a4\u30b7\u30f3 \u6d66\u7530\u793e\u9577\" srcset=\"http:\/\/m12n08.jp\/blog\/wp-content\/uploads\/2019\/12\/2019-12-22_171820-200x120.png\" sizes=\"100vw\" wpfc-lazyload-disable=\"true\" \/><\/a>\n<div class=\"pt-cv-content\">\u3053\u3093\u306b\u3061\u306f\u3001\u30b7\u30a8\u30f3\uff08@M12n08Jp)\u3067\u3059\u3002 \u3053\u306e\u30da\u30fc\u30b8\u3067\u306f\u30aa\u30f3\u30b3\u30ea\u30b9\u30d0\u30a4\u30aa\u30d5\u30a1\u30fc\u30de 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